AACR Molecular Cancer Therapeutics: TRX-E-002-1 Induces c-Jun–Dependent Apoptosis in Ovarian Cancer Stem Cells and Prevents Recurrence In Vivo
Chemoresistance is a major hurdle in the management of patients with epithelial ovarian cancer and is responsible for its high mortality. Studies have shown that chemoresistance is due to the presence of a subgroup of cancer cells with stemness properties and a high capacity for tumor repair. We have developed a library of super-benzopyran analogues to generate potent compounds that can induce cell death in chemoresistant cancer stem cells.Source: Molecular Cancer Therapeutics
British Journal of Cancer: Triapine potentiates platinum-based combination therapy by disruption of homologous recombination repair
Platinum resistance may be attributable to inherent or acquired proficiency in homologous recombination repair (HRR) in epithelial ovarian cancer (EOC). The objective of this study was to evaluate the efficacy of the small molecule inhibitor triapine to disrupt HRR and sensitise BRCA wild-type EOC cells to platinum-based combination therapy in vitro and in vivo.Source: British Journal of Cancer
Five Yale researchers awarded grants to study women’s reproductive cancers
Five researchers from the Yale School of Medicine have received grants from Discovery to Cure, a program at the Department of Obstetrics, Gynecology, and Reproductive Sciences that advances the prevention, early detection, and treatment of women’s reproductive cancers such as ovarian, uterine, cervical, vaginal, and vulvar cancers.
In Study of Veterans, Positive Personality Traits Moderate Persistent High Alcohol Consumption
Peter Na, MD, MPH, assistant professor of psychiatry, and Robert Pietrzak, PhD, MPH, professor of psychiatry and of public health, led a research team that examined the psychosocial moderators of high alcohol consumption determined by polygenic risk in military veterans.Source: Psychological Medicine
A Single Dose of Psilocybin Boosts Neuroplasticity and Reduces Depression Symptoms
Patrick Skosnik, PhD, associate professor of psychiatry, and Deepak D'Souza, MD, Albert E Kent Professor of Psychiatry, are first and senior authors, respectively, of a paper in Journal of Psychopharmacology that provides evidence that psilocybin induces lasting changes in neuroplasticity and that these changes are linked to improvements in depression symptoms.Source: PsyPost
Huckins to Receive 2023 International Society of Psychiatric Genetics Theodore Reich Early Career Award
Laura Huckins, PhD, associate professor of psychiatry, has been awarded the 2023 International Society of Psychiatric Genetics (ISPG) Theodore Reich Early Career Award. Huckins was selected for the award based on her published work describing the genetic underpinnings of eating disorders and PTSD as well as for her service to the psychiatric genetics community.
Investigators Launch Study Aimed at Accelerating Understanding of Bipolar Disorder
A multidisciplinary team of researchers based at Yale will launch a series of studies aimed at accelerating understanding of bipolar disorder and generating new and more effective treatments. Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience and Professor of Psychiatry, and in the Child Study Center and of Radiology and Biomedical Imaging, will lead the research team.
Girgenti Paper Explores 'iHerd,' A Hierarchical Graph Representation Learning Method
Matthew Girgenti, PhD, assistant professor of psychiatry, is co-author of a paper in PLOS Computational Biology that explores a hierarchical graph representation learning method called iHerd.Source: PLOS Computational Biology
Ramaswamy Praises the 'Nuclear Family,' but Single Parents Say His Comments Hurt
Carmen Black, MD, assistant professor of psychiatry, and a single parent, spoke to USA Today for a story about comments presidential candidate Vivek Ramaswamy made regarding his upbringing in a two-parent household.Source: USA Today
Distribution of CARES Act Provider Relief Funding to Psychiatric Care Organizations
John Havlik, a Yale School of Medicine student, and Jack Tsai, PhD, associate professor adjunct of psychiatry, are first and senior authors, respectively, of a paper in Psychiatric Services that tracked distribution of Coronavirus Aid, Relief, and Economic Security (CARES) Act funding among psychiatrists.Source: Psychiatric Services
Picciotto to Direct Interdepartmental Neuroscience Program
Marina Picciotto, PhD, Charles B. G. Murphy Professor of Psychiatry and Professor in the Child Study Center, of Neuroscience and of Pharmacology, has been appointed director of the Interdepartmental Neuroscience Program, the largest doctoral program in the biological and biomedical sciences at Yale.
Forray Featured Speaker at Capitol Hill Briefing
Ariadna Forray, MD, associate professor of psychiatry and director of the Center for the Wellbeing of Women and Mothers at Yale, was a featured speaker at a briefing on Capitol Hill on July 26 about the impact of the opioid epidemic on maternal health.