AACR Molecular Cancer Therapeutics: TRX-E-002-1 Induces c-Jun–Dependent Apoptosis in Ovarian Cancer Stem Cells and Prevents Recurrence In Vivo
Chemoresistance is a major hurdle in the management of patients with epithelial ovarian cancer and is responsible for its high mortality. Studies have shown that chemoresistance is due to the presence of a subgroup of cancer cells with stemness properties and a high capacity for tumor repair. We have developed a library of super-benzopyran analogues to generate potent compounds that can induce cell death in chemoresistant cancer stem cells.Source: Molecular Cancer Therapeutics
British Journal of Cancer: Triapine potentiates platinum-based combination therapy by disruption of homologous recombination repair
Platinum resistance may be attributable to inherent or acquired proficiency in homologous recombination repair (HRR) in epithelial ovarian cancer (EOC). The objective of this study was to evaluate the efficacy of the small molecule inhibitor triapine to disrupt HRR and sensitise BRCA wild-type EOC cells to platinum-based combination therapy in vitro and in vivo.Source: British Journal of Cancer
Five Yale researchers awarded grants to study women’s reproductive cancers
Five researchers from the Yale School of Medicine have received grants from Discovery to Cure, a program at the Department of Obstetrics, Gynecology, and Reproductive Sciences that advances the prevention, early detection, and treatment of women’s reproductive cancers such as ovarian, uterine, cervical, vaginal, and vulvar cancers.
Why A Psychiatric Researcher Says, ‘America Is Becoming A Justice-Addicted Nation’
James Kimmel Jr., JD, lecturer in psychiatry at Yale School of Medicine, researches revenge cravings, justice addiction, violence prevention, and mental health. Kimmel told Dr. Phil that violence is up across the country because “America is becoming a justice addicted nation.”Source: Yahoo!
Levels of Stress, Anxiety and Sadness Among Women Are at a 10-Year High, Survey Shows
Sofia Noori, MD, MPH, clinical instructor in psychiatry, spoke to USA Today about a new report that shows levels of stress, anxiety, worry, sadness, and anger among women worldwide are at a 10-year high.Source: USA Today
Moderating the Relationship Between Ulcerative Colitis and Crohn’s Disease and Symptoms of PTSD
Alexandra Fuss, PhD, assistant professor of psychiatry, is first author of a paper in Journal of Clinical Gastroenterology that examines whether inflammatory bowel disease (IBD) patients endorse clinically significant symptoms of post-traumatic stress disorder (PTSD), and tests whether remission status and remission expectations effectively moderate the relationship between endorsements of PTSD symptoms and aspects of IBD.Source: Journal of Clinical Gastroenterology
Computer-Assisted CBT May Help Alleviate Depression
Brian Kiluk, PhD, associate professor of psychiatry, spoke to Psychiatric News about a study in JAMA Network Open that indicates patients being treated for depression by their primary care doctor may benefit from participating in a 12-week computer program that teaches cognitive-behavioral therapy (CBT) skills.Source: Psychiatric News
How to Talk to a Friend Who Has Lost Someone to Suicide
Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience and Professor of Psychiatry, and in the Child Study Center and of Radiology and Biomedical Imaging, spoke to Verywell Mind about the importance of spending time with a friend if they have lost someone to suicide.Source: Verywell Mind
Job Seekers Receive Help from Bell's Virtual Reality Job Interview Training Program
A new paper published in Psychiatric Services and co-authored by Morris Bell, PhD, professor emeritus and senior research scientist in psychiatry, reveals that a virtual reality interview program does provide strong support for people seeking employment.
Polimanti Receives NIMH Grant To Study Internalizing Disorders, COVID-19
Renato Polimanti, PhD, assistant professor of psychiatry at Yale School of Medicine, has received a 3-year grant from the National Institute of Mental Health (NIMH) to evaluate the association of internalizing disorders with the risk, onset, and vulnerability of COVID-19.
Racial and Ethnic Differences in Suicidal Behavior and Mental Health Service Use Among US adults, 2009–2020
Tanner Bommersbach, MD, MPH; Robert Rosenheck, MD; and Greg Rhee, PhD, are co-authors of a paper in Cambridge University Press that studied the racial/ethnic differences in precursors to suicide among adults in the United States.Source: Cambridge University Press