Cell-Free DNA Derived From Neutrophils Triggers Type 1 Interferon Signature in Neuromyelitis Optica Spectrum Disorder
Murata H, Kinoshita M, Yasumizu Y, Motooka D, Beppu S, Shiraishi N, Sugiyama Y, Kihara K, Tada S, Koda T, Konaka H, Takamatsu H, Kumanogoh A, Okuno T, Mochizuki H. Cell-Free DNA Derived From Neutrophils Triggers Type 1 Interferon Signature in Neuromyelitis Optica Spectrum Disorder. Neurology Neuroimmunology & Neuroinflammation 2022, 9: e1149. PMID: 35210295, PMCID: PMC8874356, DOI: 10.1212/nxi.0000000000001149.Peer-Reviewed Original ResearchMeSH KeywordsCell-Free Nucleic AcidsHumansInterferonsLeukocytes, MononuclearNeuromyelitis OpticaNeutrophilsConceptsNeuromyelitis optica spectrum disorderPeripheral blood mononuclear cellsCell-free DNAAquaporin-4 antibody-positive neuromyelitis optica spectrum disorderAntibody-positive neuromyelitis optica spectrum disorderPathogenesis of neuromyelitis optica spectrum disordersToll-like receptor 9 antagonistIFN-1IFN-1 pathwayInhibition of NETosisPeripheral immune systemOrigin of cell-free DNABlood mononuclear cellsPredominant cellular sourceIFN-1 productionType 1 interferonLL37 antimicrobial peptideWhole blood transcriptome analysisAquaporin-4Mononuclear cellsCfDNA fractionDNA methylation profilesBlood transcriptome analysisHealthy subjectsCellular source