Featured Publications
Regulatory T Cell-Specific Epigenomic Region Variants Are a Key Determinant of Susceptibility to Common Autoimmune Diseases
Ohkura N, Yasumizu Y, Kitagawa Y, Tanaka A, Nakamura Y, Motooka D, Nakamura S, Okada Y, Sakaguchi S. Regulatory T Cell-Specific Epigenomic Region Variants Are a Key Determinant of Susceptibility to Common Autoimmune Diseases. Immunity 2020, 52: 1119-1132.e4. PMID: 32362325, DOI: 10.1016/j.immuni.2020.04.006.Peer-Reviewed Original ResearchMeSH KeywordsAutoimmune DiseasesBiomarkersCell DifferentiationComputational BiologyCpG IslandsDNA MethylationEpigenesis, GeneticEpigenomicsGene Expression ProfilingGenetic Predisposition to DiseaseGenetic VariationHumansImmunophenotypingPolymorphism, Single NucleotideT-Lymphocyte SubsetsT-Lymphocytes, RegulatoryTranscriptomeConceptsCommon autoimmune diseasesSingle-nucleotide polymorphismsSusceptibility to common autoimmune diseasesCell-specific gene transcriptionGenome-wide epigenetic profilingAssociated with common autoimmune diseasesAssociated with transcriptionPolygenic autoimmune diseasesTreg cellsDemethylated regionCpG hypomethylationSuper-enhancersAutoimmune diseasesDeterminants of susceptibilityEpigenetic modificationsEpigenetic profilesGene transcriptionEpigenetic changesTreg-cell-specific demethylated regionNaive Treg cellsNatural Treg cellsRegional variantsTranscriptionActive stateCells
2022
piRNA/PIWI Protein Complex as a Potential Biomarker in Sporadic Amyotrophic Lateral Sclerosis
Abdelhamid R, Ogawa K, Beck G, Ikenaka K, Takeuchi E, Yasumizu Y, Jinno J, Kimura Y, Baba K, Nagai Y, Okada Y, Saito Y, Murayama S, Mochizuki H, Nagano S. piRNA/PIWI Protein Complex as a Potential Biomarker in Sporadic Amyotrophic Lateral Sclerosis. Molecular Neurobiology 2022, 59: 1693-1705. PMID: 35015250, PMCID: PMC8882100, DOI: 10.1007/s12035-021-02686-2.Peer-Reviewed Original ResearchMeSH KeywordsAmyotrophic Lateral SclerosisArgonaute ProteinsBiomarkersHumansMotor NeuronsRNA, Small InterferingConceptsPIWI-interacting RNAsNon-coding RNAsBind to PIWI-interacting RNAsDysregulation of piRNAsControl postmortem brain samplesAmyotrophic lateral sclerosisTDP-43Biogenesis of RNAsAggregation of TAR DNA-binding protein 43RNA-binding proteinsTAR DNA-binding protein 43DNA-binding protein 43Abnormal RNA metabolismNcRNA biogenesisPIWI proteinsPiwi homologsSilencing 1Sporadic ALSRNA metabolismRNA-seqTDP-43 pathologyProtein complexesPIWIL1Sporadic amyotrophic lateral sclerosisPathological hallmark