2023
Increased anti‐oxidative action compensates for collagen tissue degeneration in vitiligo dermis
Yokoi K, Yasumizu Y, Ohkura N, Shinzawa K, Okuzaki D, Shimoda N, Ando H, Yamada N, Fujimoto M, Tanemura A. Increased anti‐oxidative action compensates for collagen tissue degeneration in vitiligo dermis. Pigment Cell & Melanoma Research 2023, 36: 355-364. PMID: 37230937, DOI: 10.1111/pcmr.13094.Peer-Reviewed Original ResearchConceptsCollagen-related genesUninvolved perilesional skinOxidative stressSignaling pathway activationCollagen homeostasisVitiligo lesionsPathway activationPerilesional skinExpression levelsAnti-oxidant enzymesAnti-oxidative actionDegraded collagen fibersNrf2 signaling pathway activationDefense systemProduction of oxidative stress
2021
Reply to Slominski et al.: UVB irradiation induces proenkephalin+ regulatory T cells with a wound-healing function
Shime H, Odanaka M, Tsuiji M, Matoba T, Imai M, Yasumizu Y, Uraki R, Minohara K, Watanabe M, Bonito A, Fukuyama H, Ohkura N, Sakaguchi S, Morita A, Yamazaki S. Reply to Slominski et al.: UVB irradiation induces proenkephalin+ regulatory T cells with a wound-healing function. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2021919118. PMID: 33414270, PMCID: PMC7826361, DOI: 10.1073/pnas.2021919118.Peer-Reviewed Original Research
2020
Proenkephalin+ regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function
Shime H, Odanaka M, Tsuiji M, Matoba T, Imai M, Yasumizu Y, Uraki R, Minohara K, Watanabe M, Bonito A, Fukuyama H, Ohkura N, Sakaguchi S, Morita A, Yamazaki S. Proenkephalin+ regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 20696-20705. PMID: 32769209, PMCID: PMC7456133, DOI: 10.1073/pnas.2000372117.Peer-Reviewed Original ResearchConceptsTreg cellsUltraviolet B exposureUnique TCR repertoireFoxp3 transcription factorRegulatory T cellsSkin homeostasisSkin explant assayImmunological self-toleranceFunctional regulatory TUltraviolet BWound healingSuppress various immune responsesEndogenous opioid precursorsSkin TregsExpressed CD25Regulatory TTCR repertoireProenkephalin expressionT cellsSelf-toleranceWound closure assayImmune responseTregsInflammatory responseMet-Enk