Neoself-antigens are the primary target for autoreactive T cells in human lupus
Mori S, Kohyama M, Yasumizu Y, Tada A, Tanzawa K, Shishido T, Kishida K, Jin H, Nishide M, Kawada S, Motooka D, Okuzaki D, Naito R, Nakai W, Kanda T, Murata T, Terao C, Ohmura K, Arase N, Kurosaki T, Fujimoto M, Suenaga T, Kumanogoh A, Sakaguchi S, Ogawa Y, Arase H. Neoself-antigens are the primary target for autoreactive T cells in human lupus. Cell 2024, 187: 6071-6087.e20. PMID: 39276775, DOI: 10.1016/j.cell.2024.08.025.Peer-Reviewed Original ResearchSystemic lupus erythematosusAutoreactive T cellsT cellsMHC-IISelf-antigensDevelopment of lupus-like diseaseCD4<sup>+</sup> T cellsEpstein-Barr virus reactivationPathogenesis of systemic lupus erythematosusRisk factorsSystemic lupus erythematosus patientsMajor histocompatibility complex class IIHistocompatibility complex class IILupus-like diseaseLupus T cellsHuman lupusGenetic risk factorsVirus reactivationLupus erythematosusAdult micePrimary targetTrigger autoimmunityClass IIPeptide presentationInvariant chain