High cell surface expression and peptide binding affinity of HLA-DQA1*05:03, a susceptible allele of neuromyelitis optica spectrum disorders (NMOSD)
Beppu S, Kinoshita M, Wilamowski J, Suenaga T, Yasumizu Y, Ogawa K, Ishikura T, Tada S, Koda T, Murata H, Shiraishi N, Sugiyama Y, Kihara K, Sugimoto T, Arase H, Standley D, Okuno T, Mochizuki H. High cell surface expression and peptide binding affinity of HLA-DQA1*05:03, a susceptible allele of neuromyelitis optica spectrum disorders (NMOSD). Scientific Reports 2022, 12: 106. PMID: 34997058, PMCID: PMC8742014, DOI: 10.1038/s41598-021-04074-1.Peer-Reviewed Original ResearchConceptsNeuromyelitis optica spectrum disorderPeptide major histocompatibility complexDevelopment of neuromyelitis optica spectrum disorderAnti-aquaporin-4HLA-DQA1Associated with neuromyelitis optica spectrum disordersHigh cell surface expressionJapanese patient cohortPresence of pathogenic autoantibodiesCell surface expression levelsRelapsing autoimmune diseaseHLA-DQA1 allelesCell surface expressionSurface expression levelsAQP4 peptidesMajor histocompatibility complexAnti-aquaporinPathogenic autoantibodiesHLA-DQPatient cohortAutoimmune diseasesPathogenic roleSurface expressionIn silico 3D structure modelingHistocompatibility complex