Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion
Harada A, Matsumoto S, Yasumizu Y, Shojima K, Akama T, Eguchi H, Kikuchi A. Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion. ELife 2021, 10: e66721. PMID: 34590580, PMCID: PMC8598236, DOI: 10.7554/elife.66721.Peer-Reviewed Original ResearchConceptsDownstream effectorsEGF-Ras pathwayCancer cell invasionPancreatic cancer patientsPancreatic cancer cellsIQGAP1ARL4CCell invasionPancreatic cancerSite of invasionCancer cellsCancer patientsExtracellular matrixPseudopodsAntisense oligonucleotidesInvasive pancreatic cancerMetastasis of pancreatic cancerActive siteInduced degradationEffectorMMP14InvasionMortality rateLocalizationOligonucleotides