A Newly Identified Gene Ahed Plays Essential Roles in Murine Hematopoiesis through RNA Splicing
Nakai R, Yokota T, Tokunaga M, Takaishi M, Yokomizo T, Sudo T, Shi H, Yasumizu Y, Okuzaki D, Kokubu C, Tanaka S, Takaoka K, Yamanishi A, Yoshida J, Watanabe H, Kondoh G, Horie K, Hosen N, Sano S, Takeda J. A Newly Identified Gene Ahed Plays Essential Roles in Murine Hematopoiesis through RNA Splicing. Blood 2024, 144: 5614-5614. DOI: 10.1182/blood-2024-209978.Peer-Reviewed Original ResearchGene trap vectorUncharacterized genesRNA splicingDatabase of protein-protein interactionsConditional knockoutRegulation of RNA splicingHomozygous mutant clonesEmbryonic stem cellsDNA sequencing technologiesHematopoietic cellsFetal liverMutant embryonic stem cellsProtein-protein interactionsBloom's syndrome geneHematopoietic systemGene expression databaseDevelopment of hematopoietic cellsMouse ESC linesGenetic abnormalitiesMRNAs of genesEssential genesSequencing technologiesInterchromosomal recombinationTrap vectorUncharacterized functionA newly identified gene Ahed plays essential roles in murine haematopoiesis
Nakai R, Yokota T, Tokunaga M, Takaishi M, Yokomizo T, Sudo T, Shi H, Yasumizu Y, Okuzaki D, Kokubu C, Tanaka S, Takaoka K, Yamanishi A, Yoshida J, Watanabe H, Kondoh G, Horie K, Hosen N, Sano S, Takeda J. A newly identified gene Ahed plays essential roles in murine haematopoiesis. Nature Communications 2024, 15: 5090. PMID: 38918373, PMCID: PMC11199565, DOI: 10.1038/s41467-024-49252-7.Peer-Reviewed Original ResearchConceptsMutant embryonic stem cellsConditional knockoutUncharacterised genesHaematopoietic cellsNuclear proteinsFunctional genesHaematopoiesis in vivoAssociated with malignancyBiological functionsGenesSomatic mutationsEmbryonic stem cellsHaematopoietic developmentTransplantation experimentsHaematological malignanciesDeletionAdult miceCancer patientsCoordinated actionEmbryonic dayStem cellsHaematopoiesisMurine haematopoiesisCellsMalignancy