ASIC3 Mediates Itch Sensation in Response to Coincident Stimulation by Acid and Nonproton Ligand
Peng Z, Li W, Huang C, Jiang Y, Wang X, Zhu M, Cheng X, Xu T. ASIC3 Mediates Itch Sensation in Response to Coincident Stimulation by Acid and Nonproton Ligand. Cell Reports 2015, 13: 387-398. PMID: 26440887, DOI: 10.1016/j.celrep.2015.09.002.Peer-Reviewed Original ResearchConceptsAcid-sensing ion channel 3Itch sensationPrimary sensory neuronsIon channel 3ASIC3 geneSL-NH2Concomitant inflammationScratching behaviorPathological changesCoincident stimulationTissue acidosisASIC3 channelsSensory neuronsAcidosisNonproton ligandPruritogensSensationIle-GlyChannel 3Arg-LeuInflammationItchMiceNeuronsDesensitizationCytotoxic T cell responses are enhanced by antigen design involving the presentation of MUC1 peptide on cholera toxin B subunit
Lu W, Qiu L, Yan Z, Lin Z, Cao M, Hu C, Wang Z, Wang J, Yu Y, Cheng X, Cao P, Li R. Cytotoxic T cell responses are enhanced by antigen design involving the presentation of MUC1 peptide on cholera toxin B subunit. Oncotarget 2015, 6: 34537-34548. PMID: 26417929, PMCID: PMC4741471, DOI: 10.18632/oncotarget.5307.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAnimalsAntigen PresentationBlotting, WesternCancer VaccinesCholera ToxinDisease Models, AnimalEpitopes, B-LymphocyteFemaleFluorescent Antibody TechniqueLymphocyte ActivationMiceMice, Inbred C57BLMinisatellite RepeatsMucin-1Polymerase Chain ReactionT-Lymphocytes, CytotoxicVaccines, SubunitConceptsCytotoxic T lymphocytesMUC1-specific cytotoxic T lymphocytesElicit cytotoxic T lymphocyteCytotoxic T cell responsesT cell responsesCancer vaccine designCholera toxin B subunitToxin B subunitB-cell epitopesMUC1 vaccineTumor burdenCancer vaccinesTh1 cellsT cellsT lymphocytesMouse modelCell epitopesTumor growthCell responsesTumor tissueVaccine designTumor MUC1Antigen designVaccineMUC1 peptide