2007
A Novel CaV1.2 N Terminus Expressed in Smooth Muscle Cells of Resistance Size Arteries Modifies Channel Regulation by Auxiliary Subunits*
Cheng X, Liu J, Asuncion-Chin M, Blaskova E, Bannister J, Dopico A, Jaggar J. A Novel CaV1.2 N Terminus Expressed in Smooth Muscle Cells of Resistance Size Arteries Modifies Channel Regulation by Auxiliary Subunits*. Journal Of Biological Chemistry 2007, 282: 29211-29221. PMID: 17699517, PMCID: PMC2276565, DOI: 10.1074/jbc.m610623200.Peer-Reviewed Original ResearchConceptsExon 1cN-terminusExon 1bAuxiliary subunitsRich N-terminusCysteine-rich N-terminusNovel alternative splicingResistance-size cerebral arteriesPlasma membrane insertionExon 1Arterial myocytesMultiple vascular functionsIsoform-dependent differencesWhole-cell current densityN-terminal variantsAlternative splicingMembrane insertionChannel regulationExon 1AMolecular identityHuman diseasesSubunitsTerminusEntry pathwaySmooth muscle cells
2006
Genetic ablation of caveolin-1 modifies Ca2+ spark coupling in murine arterial smooth muscle cells
Cheng X, Jaggar J. Genetic ablation of caveolin-1 modifies Ca2+ spark coupling in murine arterial smooth muscle cells. AJP Heart And Circulatory Physiology 2006, 290: h2309-h2319. PMID: 16428350, PMCID: PMC1698957, DOI: 10.1152/ajpheart.01226.2005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBariumCadmiumCalcium SignalingCaveolin 1ElectrophysiologyEnzyme InhibitorsFluorescent DyesFura-2IndolesMiceMice, KnockoutMicroscopy, ConfocalMicroscopy, ElectronMuscle, Smooth, VascularMyocytes, Smooth MuscleNitroargininePatch-Clamp TechniquesRyanodine Receptor Calcium Release ChannelConceptsCerebral artery smooth muscle cellsSmooth muscle cellsArtery smooth muscle cellsMuscle cellsMurine arterial smooth muscle cellsGenetic ablationNitric oxide synthase activityVoltage-dependent calcium channelsArterial smooth muscle cellsOxide synthase activitySmooth muscle contractilityChannel blockersMuscle contractilityCalcium channelsCav-1-deficient cellsSpark regulationL-typeElevated intracellularSpark frequencyPotassium channelsSarcoplasmic reticulumCurrent activationCav-1Control cellsRelease channel