2006
The Nogo–Nogo Receptor Pathway Limits a Spectrum of Adult CNS Axonal Growth
Cafferty WB, Strittmatter SM. The Nogo–Nogo Receptor Pathway Limits a Spectrum of Adult CNS Axonal Growth. Journal Of Neuroscience 2006, 26: 12242-12250. PMID: 17122049, PMCID: PMC2848954, DOI: 10.1523/jneurosci.3827-06.2006.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAxonsBehavior, AnimalCalcitonin Gene-Related PeptideCentral Nervous SystemFunctional LateralityGlial Fibrillary Acidic ProteinMiceMice, Inbred C57BLMice, KnockoutMyelin Basic ProteinMyelin ProteinsNogo ProteinsProtein Kinase CPsychomotor PerformancePyramidal TractsReceptors, PeptideSignal TransductionConceptsAxonal growthCST regenerationSpinal cord dorsal hemisectionCervical gray matterRole of NogoCorticospinal tract axonsNogo-66 receptorVivo pharmacological studiesFine motor skillsDorsal hemisectionAffected forelimbCST axonsLesion modelUnilateral pyramidotomyGray matterPharmacological studiesReceptor pathwayNogoConflicting resultsMiceMotor skillsAxonsDifferent tractsGenetic assessmentPyramidotomy
2001
Leukemia Inhibitory Factor Determines the Growth Status of Injured Adult Sensory Neurons
Cafferty W, Gardiner N, Gavazzi I, Powell J, McMahon S, Heath J, Munson J, Cohen J, Thompson S. Leukemia Inhibitory Factor Determines the Growth Status of Injured Adult Sensory Neurons. Journal Of Neuroscience 2001, 21: 7161-7170. PMID: 11549727, PMCID: PMC6762988, DOI: 10.1523/jneurosci.21-18-07161.2001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxotomyCalcitonin Gene-Related PeptideCell DivisionCell SurvivalCells, CulturedCytoprotectionFemaleGanglia, SpinalGrowth InhibitorsInjections, SpinalInterleukin-6Leukemia Inhibitory FactorLymphokinesMaleMiceMice, KnockoutNerve FibersNerve RegenerationNeuritesNeurons, AfferentPhenotypeRatsRats, WistarSciatic NerveTibial NerveConceptsLeukemia inhibitory factorLIF-/- miceAdult sensory neuronsSensory neuronsConditioning injuryInhibitory factorPeptidergic sensory neuronsMammalian sensory neuronsIntrinsic growth capacityExogenous leukemia inhibitory factorNerve damageReceptor antagonistNeuronsConditioning responseNeurite outgrowthInjuryGrowth statusVivoNormal regenerationStatusAntagonistGrowth capacityMice