2020
Gene expression in the epileptic (EL) mouse hippocampus
Lee TS, Li AY, Rapuano A, Mantis J, Eid T, Seyfried TN, de Lanerolle NC. Gene expression in the epileptic (EL) mouse hippocampus. Neurobiology Of Disease 2020, 147: 105152. PMID: 33153970, DOI: 10.1016/j.nbd.2020.105152.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyHuman temporal lobe epilepsySeizure focusHippocampal seizure focusRole of neurogliaExtensive neuronal lossMolecular changesEpileptic miceMicroglial activationNeuronal lossNeuron lossEl miceLobe epilepsySeizure modelHippocampal fieldsSeizure generationPathological changesPaucity of studiesMouse hippocampusAnimal modelsHeat shock proteinsNormal populationPathological processesExpression levelsEpilepsy
2004
Loss of glutamine synthetase in the human epileptogenic hippocampus: possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsy
Eid T, Thomas M, Spencer D, Rundén-Pran E, Lai J, Malthankar G, Kim J, Danbolt N, Ottersen O, de Lanerolle N. Loss of glutamine synthetase in the human epileptogenic hippocampus: possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsy. The Lancet 2004, 363: 28-37. PMID: 14723991, DOI: 10.1016/s0140-6736(03)15166-5.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyTemporal lobe epilepsyMTLE hippocampiLobe epilepsyExtracellular glutamateHigh extracellular glutamate concentrationsAnteromedial temporal lobeHuman epileptogenic hippocampusExtracellular glutamate accumulationResolution of seizuresExtracellular glutamate concentrationGlial glutamate transportersMeans of immunohistochemistryEpileptogenic hippocampusSurgical resectionSeizure generationGlutamate homeostasisTemporal lobeAstroglial proliferationEpileptic seizuresGlutamate transportersHippocampusTherapeutic interventionsGlutamate concentrationWestern blot