2023
Association of Body Mass Index and Waist Circumference With Imaging Metrics of Brain Integrity and Functional Connectivity in Children Aged 9 to 10 Years in the US, 2016-2018
Kaltenhauser S, Weber C, Lin H, Mozayan A, Malhotra A, Constable R, Acosta J, Falcone G, Taylor S, Ment L, Sheth K, Payabvash S. Association of Body Mass Index and Waist Circumference With Imaging Metrics of Brain Integrity and Functional Connectivity in Children Aged 9 to 10 Years in the US, 2016-2018. JAMA Network Open 2023, 6: e2314193. PMID: 37200030, PMCID: PMC10196880, DOI: 10.1001/jamanetworkopen.2023.14193.Peer-Reviewed Original ResearchConceptsBody mass indexHigher body mass indexWaist circumferenceBMI z-scoreCross-sectional studyBrain healthCross-sectional analysisFunctional connectivityMass indexMean ageInterval developmentCorpus callosumAssociation of BMIHigher baseline body mass indexBaseline cross-sectional analysisBaseline body mass indexBrain integrityResting-state functional connectivityLongitudinal analysisFuture treatment trialsABCD studyLower microstructural integrityCognitive Development StudyAdolescent Brain Cognitive Development (ABCD) studyCardiovascular implications
2022
Coordinated anatomical and functional variability in the human brain during adolescence
Bero J, Li Y, Kumar A, Humphries C, Nag S, Lee H, Ahn W, Hahn S, Constable R, Kim H, Lee D. Coordinated anatomical and functional variability in the human brain during adolescence. Human Brain Mapping 2022, 44: 1767-1778. PMID: 36479851, PMCID: PMC9921246, DOI: 10.1002/hbm.26173.Peer-Reviewed Original ResearchConceptsCortical thicknessCortical areasFunctional connectivityResting-state functional connectivityAssociation cortical areasMultiple cortical areasCortical information processingAge-related changesCortical myelinationAdult brainCytoarchitectural featuresBrain developmentInformation processingBrainDevelopmental changesHuman brainAdolescenceMyelinationPatterns of coordinationMeasuresRegional variationMyelin
2019
The individual functional connectome is unique and stable over months to years
Horien C, Shen X, Scheinost D, Constable RT. The individual functional connectome is unique and stable over months to years. NeuroImage 2019, 189: 676-687. PMID: 30721751, PMCID: PMC6422733, DOI: 10.1016/j.neuroimage.2019.02.002.Peer-Reviewed Original ResearchConceptsHigh ID ratesIndividual differencesFunctional connectomeIndividual functional connectomesStable individual differencesID rateResting-state fMRI datasetsFrontoparietal networkFunctional connectivityParietal cortexFMRI datasetsIdiosyncratic aspectsConnectomeHead motionEntire brainFMRIBrainCortexSpecific datasetDifferencesConnectivity
2017
Connectome-based Models Predict Separable Components of Attention in Novel Individuals
Rosenberg MD, Hsu WT, Scheinost D, Constable R, Chun MM. Connectome-based Models Predict Separable Components of Attention in Novel Individuals. Journal Of Cognitive Neuroscience 2017, 30: 160-173. PMID: 29040013, DOI: 10.1162/jocn_a_01197.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingAttention Network TaskExecutive controlIntrinsic functional organizationRT variabilityANT performanceInfluential modelFunctional connectivityBrain's intrinsic functional organizationComponents of attentionExecutive control scoresResting-state functional connectivityResting-state dataFunctional brain networksFunctional organizationTask-based dataAttentional abilitiesUpcoming stimulusExplicit taskSustained attentionFMRI scanningAttention factorNovel individualsAdditional independent componentNetwork tasks
2016
Language at rest: A longitudinal study of intrinsic functional connectivity in preterm children
Rowlands MA, Scheinost D, Lacadie C, Vohr B, Li F, Schneider KC, Constable R, Ment LR. Language at rest: A longitudinal study of intrinsic functional connectivity in preterm children. NeuroImage Clinical 2016, 11: 149-157. PMID: 26937383, PMCID: PMC4753807, DOI: 10.1016/j.nicl.2016.01.016.Peer-Reviewed Original ResearchConceptsLeft occipito-temporal cortexOccipito-temporal cortexVerbal IQPerformance IQLanguage deficitsSignificant connectivity reductionsPreterm childrenIntrinsic functional connectivityFull IQFunctional connectivity networksFunctional connectivityIQAge 8PT childrenConnectivity reductionLong-range connectionsWorse performanceLinear mixed effects modelsLongitudinal studyConnectivity networksAge 16PT subjectsTS childrenCortical connectivityTerm children
2009
Language lateralization in epilepsy patients: fMRI validated with the Wada procedure
Arora J, Pugh K, Westerveld M, Spencer S, Spencer DD, Constable R. Language lateralization in epilepsy patients: fMRI validated with the Wada procedure. Epilepsia 2009, 50: 2225-2241. PMID: 19490042, DOI: 10.1111/j.1528-1167.2009.02136.x.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingVerbal fluency taskWada procedureSentence comprehensionFluency taskLaterality scoresLanguage lateralizationLaterality indexAuditory sentence comprehensionFMRI language mappingAuditory taskReading taskConjunction analysisHemispheric dominanceLateralization scoresFMRI laterality indicesLanguage mappingWada testingMidline regionWada testLateralizationSpecific patient examplesQuantifying activationTaskComprehension
2005
Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation
Canli T, Congdon E, Gutknecht L, Constable R, Lesch K. Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation. Journal Of Neural Transmission 2005, 112: 1479-1485. PMID: 16245070, DOI: 10.1007/s00702-005-0391-4.Peer-Reviewed Original Research
2001
Patterns of functional magnetic resonance imaging activation in association with structural lesions in the rolandic region: a classification system.
Carpentier A, Constable R, Schlosser M, de Lotbinière A, Piepmeier J, Spencer D, Awad I. Patterns of functional magnetic resonance imaging activation in association with structural lesions in the rolandic region: a classification system. Journal Of Neurosurgery 2001, 94: 946-54. PMID: 11409524, DOI: 10.3171/jns.2001.94.6.0946.Peer-Reviewed Original ResearchConceptsFMR imaging activationSurgical interventionRolandic regionMotor cortex plasticityMotor task paradigmFunctional magnetic resonance imagingMotor skillsMagnetic resonance imagingSevere motor impairmentFunctional magnetic resonanceFunctional recoveryLesion sideCortical abnormalitiesMotor cortexControl volunteersCortical malformationsStructural lesionsContralateral hemisphereArteriovenous malformationsBrain lesionsSurgical proceduresMotor impairmentPathological lesionsFunctional reorganizationAuthors' institution
2000
The Angular Gyrus in Developmental Dyslexia: Task-Specific Differences in Functional Connectivity Within Posterior Cortex
Pugh K, Mencl W, Shaywitz B, Shaywitz S, Fulbright R, Constable R, Skudlarski P, Marchione K, Jenner A, Fletcher J, Liberman A, Shankweiler D, Katz L, Lacadie C, Gore J. The Angular Gyrus in Developmental Dyslexia: Task-Specific Differences in Functional Connectivity Within Posterior Cortex. Psychological Science 2000, 11: 51-56. PMID: 11228843, DOI: 10.1111/1467-9280.00214.Peer-Reviewed Original ResearchConceptsDevelopmental dyslexiaAngular gyrusFunctional connectivityPhonological assemblyLeft hemispherePhonological processing domainTask-specific differencesLanguage-dominant left hemispherePosterior brain regionsTemporal lobe sitesDyslexic readersNeurobiological anomaliesPhonological performanceExplicit demandDyslexiaBrain regionsGyrusPosterior cortexTaskCompensatory roleVaried demandsPosterior regionDyslexicsConnectivityHemisphere
1999
An Event-Related fMRI Study of Implicit Phrase-Level Syntactic and Semantic Processing
Kang A, Constable R, Gore J, Avrutin S. An Event-Related fMRI Study of Implicit Phrase-Level Syntactic and Semantic Processing. NeuroImage 1999, 10: 555-561. PMID: 10547332, DOI: 10.1006/nimg.1999.0493.Peer-Reviewed Original ResearchConceptsSemantic processingSemantic conditionsEvent-related fMRI paradigmEvent-related fMRI studyFunctional magnetic resonance imaging studySilent word generationMemory-related processesInferior parietal lobeAnterior cingulate gyrusMagnetic resonance imaging studyResonance imaging studyTarget stimuliTypes of discriminationWord generationBA 45FMRI paradigmOddball responseBA 44FMRI studyButton pressGrammatical judgmentOvert responseBroca's areaLanguage functionWernicke's area
1992
Multicoil high-resolution fast spin-echo MR imaging of the female pelvis.
Smith R, Reinhold C, McCauley T, Lange R, Constable R, Kier R, McCarthy S. Multicoil high-resolution fast spin-echo MR imaging of the female pelvis. Radiology 1992, 184: 671-5. PMID: 1324508, DOI: 10.1148/radiology.184.3.1324508.Peer-Reviewed Original Research