2023
Connectome-based predictive modeling shows sex differences in brain-based predictors of memory performance
Ju S, Horien C, Shen X, Abuwarda H, Trainer A, Constable R, Fredericks C. Connectome-based predictive modeling shows sex differences in brain-based predictors of memory performance. Frontiers In Dementia 2023, 2: 1126016. PMID: 39082002, PMCID: PMC11285565, DOI: 10.3389/frdem.2023.1126016.Peer-Reviewed Original ResearchDefault mode networkConnectome-based predictive modelingMemory performanceMemory taskMemory scoresShort-term memory performanceBrain-based predictorsShort-term memoryPosterior default mode networkAmnestic Alzheimer's diseaseRecollective memoryDMN activityMode networkVisual networkPast researchSex-specific modelsVisual circuitryAlzheimer's diseaseSex differencesMemoryDifferent circuitryTaskElevated riskMachine learning approachesNetwork activity
2022
Sex differences in default mode network connectivity in healthy aging adults
Ficek-Tani B, Horien C, Ju S, Xu W, Li N, Lacadie C, Shen X, Scheinost D, Constable T, Fredericks C. Sex differences in default mode network connectivity in healthy aging adults. Cerebral Cortex 2022, 33: 6139-6151. PMID: 36563018, PMCID: PMC10183749, DOI: 10.1093/cercor/bhac491.Peer-Reviewed Original ResearchConceptsDefault mode networkPreclinical Alzheimer's diseaseAlzheimer's diseaseSex differencesBrain connectivity changesDefault mode network connectivityIntrinsic connectivity distributionSeed-based analysisMode network connectivityMedial prefrontal cortexPosterior DMN nodesHealthy aging adultsImpact of sexLifetime riskDMN connectivityWhole brainPosterior cingulateDMN nodesSignificant sex differencesPrefrontal cortexConnectivity changesAging AdultsHealthy participantsDMN functionMode network
2021
Sex differences in connectivity in the default mode network in healthy aging adults
Ficek B, Horien C, Lacadie C, Shen X, Scheinost D, Constable T, Fredericks C. Sex differences in connectivity in the default mode network in healthy aging adults. Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.056050.Peer-Reviewed Original ResearchIntrinsic connectivity distributionDefault mode networkAlzheimer's diseaseHealthy aging adultsElevated riskAging AdultsLarge cross-sectional studyPosterior default mode networkSex differencesMode networkCross-sectional cohortCross-sectional studyPreclinical Alzheimer's diseaseSymptomatic Alzheimer's diseaseResting-state scansSex-based differencesAnterior nodeAD showDMN connectivityHealthy adultsFunctional MRI dataNormal individualsResults FemalesZ-scoreFunctional connectivity
1996
Cerebral organization of component processes in reading
Pugh K, Shaywitz B, Shaywitz S, Constable R, Skudlarski P, Fulbright R, Bronen R, Shankweiler D, Katz L, Fletcher J, Gore J. Cerebral organization of component processes in reading. Brain 1996, 119: 1221-1238. PMID: 8813285, DOI: 10.1093/brain/119.4.1221.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingCerebral organizationTemporal sitesLexical-semantic processingReading-related processesWord identification processOrthographic processingPhonological processingSuperior temporal sitesSemantic tasksComponent processesSignificant sex differencesSex differencesProcessingPhonologicalThe Functional Organization of Brain for Reading and Reading Disability (Dyslexia
Shaywitz B, Shaywitz S, Pugh K, Skudlarski P, Fulbright R, Constable R, Fletcher J, Liberman A, Shankweiler D, Katz L, Bronen R, Marchione K, Lacadie C, Gore J. The Functional Organization of Brain for Reading and Reading Disability (Dyslexia. The Neuroscientist 1996, 2: 245-255. DOI: 10.1177/107385849600200413.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingPhonological processingLeft inferior frontal gyrusCore cognitive componentLexical-semantic processingInferior frontal gyrusFunctional organizationPhonological tasksCognitive componentsIFG regionsReading DisabilitiesFrontal gyrusComponent processesLanguage functionBilateral activationLinguistic systemWomen's performanceDyslexiaSex differencesReadingConsistent findingCerebral localizationProcessingTaskLanguage
1995
Sex differences in the functional organization of the brain for language
Shaywitz B, Shaywltz S, Pugh K, Constable R, Skudlarski P, Fulbright R, Bronen R, Fletcher J, Shankweiler D, Katz L, Gore J. Sex differences in the functional organization of the brain for language. Nature 1995, 373: 607-609. PMID: 7854416, DOI: 10.1038/373607a0.Peer-Reviewed Original ResearchConceptsLeft inferior frontal gyrus regionsInferior frontal gyrus regionsRight inferior frontal gyrusSex differencesInferior frontal gyrusFunctional organizationPattern of activationRight-handed subjectsPhonological processingPhonological tasksSemantic tasksBrain activationFrontal gyrusLanguage functionNeural systemsGyrus regionsCerebral hemispheresTaskLanguageBrainGyrusOrganizationMalesProcessingActivation