2022
Sex differences in default mode network connectivity in healthy aging adults
Ficek-Tani B, Horien C, Ju S, Xu W, Li N, Lacadie C, Shen X, Scheinost D, Constable T, Fredericks C. Sex differences in default mode network connectivity in healthy aging adults. Cerebral Cortex 2022, 33: 6139-6151. PMID: 36563018, PMCID: PMC10183749, DOI: 10.1093/cercor/bhac491.Peer-Reviewed Original ResearchConceptsDefault mode networkPreclinical Alzheimer's diseaseAlzheimer's diseaseSex differencesBrain connectivity changesDefault mode network connectivityIntrinsic connectivity distributionSeed-based analysisMode network connectivityMedial prefrontal cortexPosterior DMN nodesHealthy aging adultsImpact of sexLifetime riskDMN connectivityWhole brainPosterior cingulateDMN nodesSignificant sex differencesPrefrontal cortexConnectivity changesAging AdultsHealthy participantsDMN functionMode network
2020
Increased connectivity in several bilateral frontal and fronto‐parietal networks predicts depressive symptoms in mid‐ to late‐life diabetics
Salardini A, Shen X, Hashemi‐Aghdam A, Laltoo E, Savoia S, Tokoglu F, Constable T. Increased connectivity in several bilateral frontal and fronto‐parietal networks predicts depressive symptoms in mid‐ to late‐life diabetics. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.043619.Peer-Reviewed Original ResearchDepressive symptomsBeck Depression InventoryDiabetic individualsBDI scoresDepression InventoryPrefrontal cortexBackground Depressive symptomsLate-life diabetesVascular cognitive impairmentDiagnosis of diabetesHigher BDI scoresComprehensive neuropsychological testingDorsal prefrontal cortexBilateral ventromedial prefrontal cortexRs-fMRI dataDiabetic patientsFazekas scoreMoCA scoresNeuropsychological testingFunctional connectivity matricesCognitive impairmentDepression symptomsVentromedial prefrontal cortexSymptomsRs-fMRI
2016
Reorganization of brain connectivity in obesity
Geha P, Cecchi G, Constable R, Abdallah C, Small DM. Reorganization of brain connectivity in obesity. Human Brain Mapping 2016, 38: 1403-1420. PMID: 27859973, PMCID: PMC6866793, DOI: 10.1002/hbm.23462.Peer-Reviewed Original ResearchConceptsGlobal brain connectivityDorsal attention networkPeripheral metabolic dysfunctionHum Brain MappSuperior parietal lobuleSomatomotor cortexMetabolic dysfunctionVentrolateral prefrontal cortexPremotor areasCaudate nucleusNeurocognitive impairmentObesityAnterior hippocampusVisual cortexBrain regionsParietal lobuleBrain functionPrefrontal cortexBrain connectivityMilkshake consumptionCortexFeeding decisionsBrain organizationInsulaHomeostatic state
1996
Activation of Human Prefrontal Cortex during Spatial and Nonspatial Working Memory Tasks Measured by Functional MRI
McCarthy G, Puce A, Constable T, Krystal J, Gore J, Goldman-Rakic P. Activation of Human Prefrontal Cortex during Spatial and Nonspatial Working Memory Tasks Measured by Functional MRI. Cerebral Cortex 1996, 6: 600-611. PMID: 8670685, DOI: 10.1093/cercor/6.4.600.Peer-Reviewed Original ResearchConceptsMiddle frontal gyrusMemory taskPrefrontal cortexHuman prefrontal cortexShape taskFrontal gyrusLeft hemisphereNonspatial working memory tasksSuccessive visual stimuliWorking Memory TaskInferior frontal gyrusTarget detection taskFunctional magnetic resonanceMnemonic contentMnemonic componentsPFC activationMemory domainAreas of activationMemory processesTask onsetVisual stimuliHemispheric activationRight hemisphereDetection taskFunctional MRI