2020
Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain
Makary MM, Polosecki P, Cecchi GA, DeAraujo IE, Barron DS, Constable TR, Whang PG, Thomas DA, Mowafi H, Small DM, Geha P. Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 10015-10023. PMID: 32312809, PMCID: PMC7211984, DOI: 10.1073/pnas.1918682117.Peer-Reviewed Original ResearchConceptsChronic low back pain patientsLow back pain patientsChronic painPain patientsChronic phaseChronic back pain patientsBack pain patientsRostral anterior cingulate cortexAnterior cingulate cortexAdditional independent datasetsRisk of transitionResting-state activityPersistent painBack painAccumbens volumeHealthy controlsNucleus accumbensPainSeparate cohortPatientsCingulate cortexPrevalent diseaseFunctional connectivityLoss of nucleiSubcortical signatures
2019
Differential Resting State Connectivity Responses to Glycemic State in Type 1 Diabetes
Parikh L, Seo D, Lacadie C, Belfort-Deaguiar R, Groskreutz D, Hamza M, Dai F, Scheinost D, Sinha R, Constable R, Sherwin R, Hwang JJ. Differential Resting State Connectivity Responses to Glycemic State in Type 1 Diabetes. The Journal Of Clinical Endocrinology & Metabolism 2019, 105: dgz004. PMID: 31511876, PMCID: PMC6936965, DOI: 10.1210/clinem/dgz004.Peer-Reviewed Original ResearchConceptsState functional connectivityHealthy controlsDefault mode networkType 1 diabetes mellitusFunctional connectivityImpact of T1DMAcademic medical centerAngular gyrus connectivityBlood oxygenation levelState connectivity patternsFunctional connectivity analysisHyperinsulinemic euglycemicHypoglycemic unawarenessHypoglycemia unawarenessDiabetes mellitusHypoglycemic clampHypoglycemia awarenessFunctional outcomeMild hypoglycemiaGlycemic stateObservational studyMedical CenterT1DMHC volunteersType 1Differential resting state connectivity responses to glycemic state in type 1 diabetes
Parikh L, Seo D, Lacadie C, Belfort-DeAguiar R, Groskreutz D, Hamza M, Dai F, Scheinost D, Sinha R, Constable R, Sherwin R, Hwang J. Differential resting state connectivity responses to glycemic state in type 1 diabetes. The Journal Of Clinical Endocrinology & Metabolism 2019 DOI: 10.1210/jcem/dgz004.Peer-Reviewed Original ResearchType 1 diabetesState functional connectivityHealthy controlsDefault mode networkFunctional connectivityImpact of T1DMHealthy control volunteersAcademic medical centerAngular gyrus connectivityState connectivity patternsFunctional connectivity analysisHyperinsulinemic euglycemicHypoglycemic unawarenessHypoglycemia unawarenessHypoglycemic clampHypoglycemia awarenessFunctional outcomeControl volunteersMild hypoglycemiaGlycemic stateObservational studyMedical CenterT1DMHypoglycemiaNeurocognitive consequences