2001
Three Pairs of Cysteine Residues Mediate Both Redox and Zn2+ Modulation of the NMDA Receptor
Choi Y, Chen H, Lipton S. Three Pairs of Cysteine Residues Mediate Both Redox and Zn2+ Modulation of the NMDA Receptor. Journal Of Neuroscience 2001, 21: 392-400. PMID: 11160420, PMCID: PMC6763802, DOI: 10.1523/jneurosci.21-02-00392.2001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesCells, CulturedCysteineDithiothreitolDose-Response Relationship, DrugDrug SynergismGlycineHistidineMesylatesMutagenesis, Site-DirectedN-MethylaspartateOocytesOxidation-ReductionPatch-Clamp TechniquesReceptors, N-Methyl-D-AspartateStructure-Activity RelationshipSulfhydryl ReagentsTransfectionXenopusZinc
1999
Identification and Mechanism of Action of Two Histidine Residues Underlying High-Affinity Zn2+ Inhibition of the NMDA Receptor
Choi Y, Lipton S. Identification and Mechanism of Action of Two Histidine Residues Underlying High-Affinity Zn2+ Inhibition of the NMDA Receptor. Neuron 1999, 23: 171-180. PMID: 10402203, DOI: 10.1016/s0896-6273(00)80763-1.Peer-Reviewed Original ResearchConceptsNR1/NR2B receptorsNR1/NR2ANR2B receptorsN-methyl-D-aspartate receptor activityMechanism of actionExtracellular N-terminal domainXenopus oocyte expression systemNMDA receptorsVoltage-dependent componentVoltage-dependent blockOocyte expression systemReceptor activityHigh-affinity Zn2Recombinant NR1/NR2ANR2AProton inhibitionReceptorsInhibitionZinc inhibitionCritical determinantHigh affinityNMDANMDAR