1994
Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders
Epstein F, Lipton S, Rosenberg P. Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders. New England Journal Of Medicine 1994, 330: 613-622. PMID: 7905600, DOI: 10.1056/nejm199403033300907.Peer-Reviewed Original ResearchGreater sensitivity of larger retinal ganglion cells to NMDA-mediated cell death
Dreyer E, Pan Z, Storm S, Lipton S. Greater sensitivity of larger retinal ganglion cells to NMDA-mediated cell death. Neuroreport 1994, 5: 629-631. PMID: 7912962, DOI: 10.1097/00001756-199401000-00024.Peer-Reviewed Original ResearchConceptsLarge retinal ganglion cellsRetinal ganglion cellsGanglion cellsGlutamate-mediated cell deathN-methyl-D-aspartate (NMDA) subtypeIntact rat eyesCell deathNeuronal lossGlutamate toxicityGlutamate receptorsRat eyesPattern of lossNMDAGlaucomaToxic effectsDeathCellsGlutamateTissue cultureGreater sensitivitySubtypesNeuronsSimilar fashionReceptors
1993
Delayed administration of memantine prevents N‐methyl‐D‐aspartate receptor‐mediated neurotoxicity
Pellegrini J, Lipton S. Delayed administration of memantine prevents N‐methyl‐D‐aspartate receptor‐mediated neurotoxicity. Annals Of Neurology 1993, 33: 403-407. PMID: 8098195, DOI: 10.1002/ana.410330414.Peer-Reviewed Original ResearchConceptsExcitatory amino acidsN-methyl-D-aspartate receptor-mediated neurotoxicityPotent N-methyl-D-aspartate antagonistNeonatal rat retinal ganglion cellsN-methyl-D-aspartate (NMDA) subtypeN-methyl-D-aspartate antagonistsRat retinal ganglion cellsImmunodeficiency syndrome (AIDS) dementiaAcute neurological conditionsHypoxia/ischemiaChronic neurodegenerative diseasesRetinal ganglion cellsNeuronal cell deathMicroM memantineAntiparkinsonian drugsCentral neuronsGanglion cellsExcessive activationGlutamate receptorsNeurological conditionsNeurodegenerative diseasesHuntington's diseaseNeurotoxicityPrimary culturesDisease
1991
Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity
Lipton S, Sucher N, Kaiser P, Dreyer E. Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity. Neuron 1991, 7: 111-118. PMID: 1676893, DOI: 10.1016/0896-6273(91)90079-f.Peer-Reviewed Original ResearchConceptsNMDA receptor-mediated neurotoxicityHIV-1 coat protein gp120Whole-cell patch-clamp recordingsHIV coat proteinRat retinal culturesSubsequent neuronal damagePatch-clamp recordingsGlutamate pyruvate transaminaseNeuronal injuryNeuronal damageEndogenous glutamateGanglion cellsNMDA antagonistsProtein gp120Low picomolar concentrationsRetinal culturesGp120NeurotoxicityComplete protectionMinute increasePicomolar concentrationsGlutamateInjuryAntagonistTransaminaseCalcium channel antagonists attenuate NMDA receptor-mediated neurotoxicity of retinal ganglion cells in culture
Sucher N, Lei S, Lipton S. Calcium channel antagonists attenuate NMDA receptor-mediated neurotoxicity of retinal ganglion cells in culture. Brain Research 1991, 551: 297-302. PMID: 1680525, DOI: 10.1016/0006-8993(91)90944-q.Peer-Reviewed Original ResearchConceptsCalcium channel antagonistsRetinal ganglion cellsChannel antagonistsGanglion cellsPostnatal rat retinal ganglion cellsNMDA receptor-operated channelsRat retinal ganglion cellsNMDA receptor-mediated neurotoxicityVoltage-dependent calcium channelsSelective NMDA antagonistDihydropyridine calcium channel antagonistReceptor-operated channelsVoltage-dependent Ca2Patch-clamp recordingsNMDA antagonistsNMDA receptorsSubsequent toxic effectsCalcium channelsExogenous glutamateRetinal culturesAntagonistL-typeEarly riseInjurious effectsToxic effects
1988
Central mammalian neurons normally resistant to glutamate toxicity are made sensitive by elevated extracellular Ca2+: toxicity is blocked by the N-methyl-D-aspartate antagonist MK-801.
Hahn J, Aizenman E, Lipton S. Central mammalian neurons normally resistant to glutamate toxicity are made sensitive by elevated extracellular Ca2+: toxicity is blocked by the N-methyl-D-aspartate antagonist MK-801. Proceedings Of The National Academy Of Sciences Of The United States Of America 1988, 85: 6556-6560. PMID: 2901101, PMCID: PMC282012, DOI: 10.1073/pnas.85.17.6556.Peer-Reviewed Original ResearchConceptsAntagonist MK-801MK-801N-methyl-D-aspartate (NMDA) receptor-coupled ion channelsExtracellular Ca2N-methyl-D-aspartate antagonist MK-801Rat retinal ganglion cellsReceptor-coupled ion channelsGlutamate-induced cell deathCentral mammalian neuronsRetinal ganglion cellsElevated extracellular Ca2Severe neurological insultPatch-clamp experimentsDementia complexNeuronal deathCentral neuronsGanglion cellsNeurological insultNeurotoxic effectsAlzheimer's diseaseNeurological disordersDegenerative disordersNerve cellsMammalian neuronsHuntington's disease