Identification and Mechanism of Action of Two Histidine Residues Underlying High-Affinity Zn2+ Inhibition of the NMDA Receptor
Choi Y, Lipton S. Identification and Mechanism of Action of Two Histidine Residues Underlying High-Affinity Zn2+ Inhibition of the NMDA Receptor. Neuron 1999, 23: 171-180. PMID: 10402203, DOI: 10.1016/s0896-6273(00)80763-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDiethyl PyrocarbonateFemaleHistidineMutationOocytesPatch-Clamp TechniquesProtein IsoformsReceptors, N-Methyl-D-AspartateXenopus laevisZincConceptsNR1/NR2B receptorsNR1/NR2ANR2B receptorsN-methyl-D-aspartate receptor activityMechanism of actionExtracellular N-terminal domainXenopus oocyte expression systemNMDA receptorsVoltage-dependent componentVoltage-dependent blockOocyte expression systemReceptor activityHigh-affinity Zn2Recombinant NR1/NR2ANR2AProton inhibitionReceptorsInhibitionZinc inhibitionCritical determinantHigh affinityNMDANMDAR