1999
Neuroprotection by the NMDA receptor-associated open-channel blocker memantine in a photothrombotic model of cerebral focal ischemia in neonatal rat
Stieg P, Sathi S, Warach S, Le D, Lipton S. Neuroprotection by the NMDA receptor-associated open-channel blocker memantine in a photothrombotic model of cerebral focal ischemia in neonatal rat. European Journal Of Pharmacology 1999, 375: 115-120. PMID: 10443569, DOI: 10.1016/s0014-2999(99)00214-9.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSide effectsInfarct sizeNeonatal ratsChannel blockersNMDA receptorsFocal cerebral ischemia modelNeurobehavioral side effectsIschemic brain injuryEffects of memantineExcitatory amino acidsInduction of strokeRodent stroke modelsAdult animal modelsCerebral ischemia modelSubstantial side effectsCerebral focal ischemiaNumerous side effectsNeuronal cell culturesNeonatal neuronsPhotochemical thrombosisPhotothrombotic modelNeuronal injuryCerebral ischemiaFocal ischemiaMice Deficient in Mac-1 (CD11b/CD18) Are Less Susceptible to Cerebral Ischemia/Reperfusion Injury
Soriano S, Coxon A, Wang Y, Frosch M, Lipton S, Hickey P, Mayadas T. Mice Deficient in Mac-1 (CD11b/CD18) Are Less Susceptible to Cerebral Ischemia/Reperfusion Injury. Stroke 1999, 30: 134-139. PMID: 9880401, DOI: 10.1161/01.str.30.1.134.Peer-Reviewed Original ResearchConceptsTransient focal cerebral ischemiaRegional cerebral blood flowMac-1-deficient miceFocal cerebral ischemiaCerebral blood flowMac-1Cerebral ischemiaBrain sectionsBlood flowCerebral ischemia/reperfusion injuryFocal ischemia/reperfusionIschemia/reperfusion injuryLeft middle cerebral arteryCerebral cell deathLeukocyte beta2 integrinsIschemic brain tissueReperfusion-induced injuryMiddle cerebral arteryIschemia/reperfusionWild-type miceLaser Doppler flowmeterWild-type cohortsMac-1 deficiencyMacrophage-1 antigenInfarct volume
1997
Janus faces of NF-κB: Neurodestruction versus neuroprotection
Lipton S. Janus faces of NF-κB: Neurodestruction versus neuroprotection. Nature Medicine 1997, 3: 20-22. PMID: 8986730, DOI: 10.1038/nm0197-20.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Inflammatory Agents, Non-SteroidalAntigens, CDApoptosisAspirinCell DeathCerebrovascular DisordersCyclooxygenase InhibitorsDose-Response Relationship, DrugHumansNeuronsNF-kappa BReactive Oxygen SpeciesReceptors, Tumor Necrosis FactorReceptors, Tumor Necrosis Factor, Type ISignal TransductionTumor Necrosis Factor-alpha
1982
Diagnosis of stroke by CPK isoenzymes
Lipton S, Samuels M. Diagnosis of stroke by CPK isoenzymes. Annals Of Neurology 1982, 11: 434-435. PMID: 7103422, DOI: 10.1002/ana.410110422.Peer-Reviewed Original ResearchCardiovascular DiseasesCerebrovascular DisordersClinical Enzyme TestsCreatine KinaseHumansIsoenzymes