2021
Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation
Xian H, Liu Y, Rundberg Nilsson A, Gatchalian R, Crother T, Tourtellotte W, Zhang Y, Aleman-Muench G, Lewis G, Chen W, Kang S, Luevanos M, Trudler D, Lipton S, Soroosh P, Teijaro J, de la Torre J, Arditi M, Karin M, Sanchez-Lopez E. Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation. Immunity 2021, 54: 1463-1477.e11. PMID: 34115964, PMCID: PMC8189765, DOI: 10.1016/j.immuni.2021.05.004.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeInflammasome activationSARS-CoV-2-induced acute respiratory distress syndromeMyeloid-specific ablationSevere COVID-19Anti-diabetic medicationsAnti-inflammatory effectsRespiratory distress syndromeIL-6 secretionNLRP3 inflammasome activationHigh mortality rateCOVID-19 lungsInhibition of ATPDistress syndromePulmonary inflammationIL-6Inflammatory conditionsMetformin inhibitionMetformin inhibitsARDS severityNF-κBNLRP3 ligandsMortality rateAlveolar macrophagesDNA synthesis
2006
Mitochondrial fission is an upstream and required event for bax foci formation in response to nitric oxide in cortical neurons
Yuan H, Gerencser A, Liot G, Lipton S, Ellisman M, Perkins G, Bossy-Wetzel E. Mitochondrial fission is an upstream and required event for bax foci formation in response to nitric oxide in cortical neurons. Cell Death & Differentiation 2006, 14: 462-471. PMID: 17053808, DOI: 10.1038/sj.cdd.4402046.Peer-Reviewed Original ResearchConceptsMitochondrial fissionNitric oxideFoci formationCortical neuronsMitochondrial fission machineryBcl-2 familyNitrosative stressAntiapoptotic Bcl-xLNeuronal cell deathFission machineryMitofusin 1Puncta formationBioenergetic crisisBax accumulationMitochondrial inhibitorsNeuronal demiseBcl-xLCell deathMitochondrial dysfunctionMitochondriaNeurodegenerative disordersNO donorNeuronsScission siteFission
2000
Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons
Budd S, Tenneti L, Lishnak T, Lipton S. Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 6161-6166. PMID: 10811898, PMCID: PMC18575, DOI: 10.1073/pnas.100121097.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsApoptosisBongkrekic AcidCaspase 3Caspase 8Caspase 9CaspasesCerebral CortexCytochrome c GroupEnzyme ActivationEnzyme InhibitorsIntracellular MembranesMitochondriaMitochondrial ADP, ATP TranslocasesNerve Tissue ProteinsNeuronsPermeabilityProtein Kinase InhibitorsReceptors, N-Methyl-D-AspartateStaurosporineConceptsAdenine nucleotide translocatorBongkrekic acidCaspase-3 activationMitochondrial adenine nucleotide translocatorCyt cReceptor-mediated apoptosisApoptotic signaling pathwaysMitochondrial permeability transition poreMitochondrial membrane potentialPermeability transition poreStaurosporine-induced activationCellular ATP contentStaurosporine resultsPutative componentsCerebrocortical neuronsNucleotide translocatorCaspase activityCaspase-8Signaling pathwaysTransition poreMitochondrial dysfunctionCytochrome cDistinct pathwaysCultured cerebrocortical neuronsApoptosis