2005
HIV-1 infection and AIDS: consequences for the central nervous system
Kaul M, Zheng J, Okamoto S, Gendelman H, Lipton S. HIV-1 infection and AIDS: consequences for the central nervous system. Cell Death & Differentiation 2005, 12: 878-892. PMID: 15832177, DOI: 10.1038/sj.cdd.4401623.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAIDS Dementia ComplexAnimalsAntiretroviral Therapy, Highly ActiveApoptosisApoptosis Regulatory ProteinsBrainChemokinesForecastingHIV Envelope Protein gp120HIV-1HumansMembrane GlycoproteinsMicrogliaNerve DegenerationNeuronsReceptors, ChemokineSignal TransductionStem CellsTNF-Related Apoptosis-Inducing LigandTumor Necrosis Factor-alphaConceptsHuman immunodeficiency virus-1Glutamate receptor-mediated excitotoxicityReceptor-mediated excitotoxicityHIV-1 infectionImmune competent cellsExtracellular matrix-degrading enzymesImmunodeficiency virus-1Central nervous systemFuture therapeutic interventionsMatrix-degrading enzymesFrank dementiaInflammatory mediatorsNeuronal damageMotor dysfunctionChemokine receptorsGlial functionDegenerative mechanismsNeurological problemsParticular macrophagesBehavioral abnormalitiesNervous systemTherapeutic interventionsNeuropathological responsesVirus 1Infection
1999
Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis
Kaul M, Lipton S. Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 8212-8216. PMID: 10393974, PMCID: PMC22214, DOI: 10.1073/pnas.96.14.8212.Peer-Reviewed Original ResearchMeSH KeywordsAIDS Dementia ComplexAnimalsApoptosisCells, CulturedCerebral CortexChemokine CCL4Chemokine CCL5Chemokine CXCL12ChemokinesCytokinesEmbryo, MammalianHIV Envelope Protein gp120HIV-1HumansImmunoglobulin FragmentsMacrophage ActivationMacrophage Inflammatory ProteinsMacrophagesNeurogliaNeuronsOligopeptidesRatsRats, Sprague-DawleyRecombinant ProteinsT-LymphocytesConceptsMacrophages/microgliaNeuronal apoptosisChemokine receptorsSDF-1Brain macrophages/microgliaStromal cell-derived factorRat cerebrocortical culturesBeta-chemokines RANTESCell-derived factorNeurotoxic factorsP38 mitogen-activated protein kinase (MAPK) pathwayProportion of cellsInflammatory proteinP38 mitogen-activated protein kinaseGp120SF2Cerebrocortical culturesReceptor CXCR4MicrogliaHuman neuronsHIV gp120CXCR4 receptorMitogen-activated protein kinase pathwayMitogen-activated protein kinaseNeuronsGp120