2000
Antiapoptotic role of the p38 mitogen-activated protein kinase–myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation
Okamoto S, Krainc D, Sherman K, Lipton S. Antiapoptotic role of the p38 mitogen-activated protein kinase–myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 7561-7566. PMID: 10852968, PMCID: PMC16585, DOI: 10.1073/pnas.130502697.Peer-Reviewed Original ResearchConceptsMyocyte enhancer factor 2Mitogen-activated protein kinase p38alphaNeuronal differentiationDominant-negative p38alphaProtein kinase p38alphaDominant-negative formTranscription factor pathwaysMADS familyMEF2 familyMEF2 pathwayCell divisionTranscription factorsMyogenic phenotypeExpression patternsMyogenic factorsAntiapoptotic roleCell deathMammalian cerebral cortexP38alphaApoptotic deathNegative formPrecursor cellsFactor 2Factor pathwayApoptosis
1998
Synergistic Activation of theN-Methyl-d-aspartate Receptor Subunit 1 Promoter by Myocyte Enhancer Factor 2C and Sp1*
Krainc D, Bai G, Okamoto S, Carles M, Kusiak J, Brent R, Lipton S. Synergistic Activation of theN-Methyl-d-aspartate Receptor Subunit 1 Promoter by Myocyte Enhancer Factor 2C and Sp1*. Journal Of Biological Chemistry 1998, 273: 26218-26224. PMID: 9748305, DOI: 10.1074/jbc.273.40.26218.Peer-Reviewed Original ResearchMeSH KeywordsBinding SitesCell LineDNA-Binding ProteinsEpidermal Growth FactorFibroblast Growth Factor 2Gene Expression Regulation, DevelopmentalMEF2 Transcription FactorsMyogenic Regulatory FactorsNerve Tissue ProteinsNuclear ProteinsPromoter Regions, GeneticProtein BindingReceptors, N-Methyl-D-AspartateRNA, MessengerSp1 Transcription FactorTranscriptional ActivationConceptsMyocyte enhancer factor 2CSp1 sitesSp1 proteinMEF2 siteFactor 2CNMDA receptor subunit 1Results of yeastNR1 promoterMuscle transcription factorsCo-immunoprecipitation experimentsDifferentiated P19 cellsGrowth factorGrowth factor regulationTwo-hybridActivation domainSp1 cDNAEssential subunitTranscription factorsEpidermal growth factorP19 cellsFactor regulationPromoter activityFibroblast growth factorBasic fibroblast growth factorNeuronal development
1995
Assignment of Human Myocyte-Specific Enhancer Binding Factor 2C (hMEF2C) to Human Chromosome 5q14 and Evidence That MEF2C Is Evolutionarily Conserved
Krainc D, Haas M, Ward D, Lipton S, Bruns G, Leifer D. Assignment of Human Myocyte-Specific Enhancer Binding Factor 2C (hMEF2C) to Human Chromosome 5q14 and Evidence That MEF2C Is Evolutionarily Conserved. Genomics 1995, 29: 809-811. PMID: 8575784, DOI: 10.1006/geno.1995.9927.Peer-Reviewed Original ResearchAnimalsBase SequenceBiological EvolutionBrainChromosome MappingChromosomes, Human, Pair 5Conserved SequenceDNA PrimersDNA-Binding ProteinsGene LibraryHumansHybrid CellsKaryotypingMADS Domain ProteinsMammalsMEF2 Transcription FactorsMolecular Sequence DataMyogenic Regulatory FactorsPolymerase Chain ReactionRestriction MappingRodentiaTranscription Factors
1993
hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors.
McDermott J, Cardoso M, Yu Y, Andres V, Leifer D, Krainc D, Lipton S, Nadal-Ginard B. hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors. Molecular And Cellular Biology 1993, 13: 2564-2577. PMID: 8455629, PMCID: PMC359588, DOI: 10.1128/mcb.13.4.2564.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingAmino Acid SequenceAnimalsBase SequenceBrainCells, CulturedCloning, MolecularConsensus SequenceDNA-Binding ProteinsGene ExpressionGenesHumansImmunologic TechniquesIn Vitro TechniquesMEF2 Transcription FactorsMiceMolecular Sequence DataMusclesMyogenic Regulatory FactorsNeuronsOligodeoxyribonucleotidesPolymerase Chain ReactionRNA, MessengerSequence AlignmentTissue DistributionTranscription FactorsTranscription, GeneticConceptsSkeletal muscleSubset of neuronsCortical neuronsBrain-specific transcription factorTranscription factorsMRNA levelsPotential targetTrans-activating activityMuscleMEF2 transcription factorsNeuronsBrainBrain transcriptsMEF2 factorsMuscle-specific enhancerExpressionMyogenic differentiationTissue-specific isoformsUbiquitous expressionFactorsTissue-specific patternsGenesNeurogenesisMEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex.
Leifer D, Krainc D, Yu Y, McDermott J, Breitbart R, Heng J, Neve R, Kosofsky B, Nadal-Ginard B, Lipton S. MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 1546-1550. PMID: 7679508, PMCID: PMC45911, DOI: 10.1073/pnas.90.4.1546.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBeta-GalactosidaseBlotting, NorthernBrainCerebral CortexChloramphenicol O-AcetyltransferaseCloning, MolecularDNADNA-Binding ProteinsFetusGene LibraryGenetic VectorsHumansMADS Domain ProteinsMEF2 Transcription FactorsMolecular Sequence DataMultigene FamilyMyogenic Regulatory FactorsOrgan SpecificityRatsRecombinant Fusion ProteinsRNASequence Homology, Amino AcidTranscription FactorsTransfection