2001
Three Pairs of Cysteine Residues Mediate Both Redox and Zn2+ Modulation of the NMDA Receptor
Choi Y, Chen H, Lipton S. Three Pairs of Cysteine Residues Mediate Both Redox and Zn2+ Modulation of the NMDA Receptor. Journal Of Neuroscience 2001, 21: 392-400. PMID: 11160420, PMCID: PMC6763802, DOI: 10.1523/jneurosci.21-02-00392.2001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesCells, CulturedCysteineDithiothreitolDose-Response Relationship, DrugDrug SynergismGlycineHistidineMesylatesMutagenesis, Site-DirectedN-MethylaspartateOocytesOxidation-ReductionPatch-Clamp TechniquesReceptors, N-Methyl-D-AspartateStructure-Activity RelationshipSulfhydryl ReagentsTransfectionXenopusZinc
1998
Synergistic Activation of theN-Methyl-d-aspartate Receptor Subunit 1 Promoter by Myocyte Enhancer Factor 2C and Sp1*
Krainc D, Bai G, Okamoto S, Carles M, Kusiak J, Brent R, Lipton S. Synergistic Activation of theN-Methyl-d-aspartate Receptor Subunit 1 Promoter by Myocyte Enhancer Factor 2C and Sp1*. Journal Of Biological Chemistry 1998, 273: 26218-26224. PMID: 9748305, DOI: 10.1074/jbc.273.40.26218.Peer-Reviewed Original ResearchMeSH KeywordsBinding SitesCell LineDNA-Binding ProteinsEpidermal Growth FactorFibroblast Growth Factor 2Gene Expression Regulation, DevelopmentalMEF2 Transcription FactorsMyogenic Regulatory FactorsNerve Tissue ProteinsNuclear ProteinsPromoter Regions, GeneticProtein BindingReceptors, N-Methyl-D-AspartateRNA, MessengerSp1 Transcription FactorTranscriptional ActivationConceptsMyocyte enhancer factor 2CSp1 sitesSp1 proteinMEF2 siteFactor 2CNMDA receptor subunit 1Results of yeastNR1 promoterMuscle transcription factorsCo-immunoprecipitation experimentsDifferentiated P19 cellsGrowth factorGrowth factor regulationTwo-hybridActivation domainSp1 cDNAEssential subunitTranscription factorsEpidermal growth factorP19 cellsFactor regulationPromoter activityFibroblast growth factorBasic fibroblast growth factorNeuronal developmentIncreased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A
Das S, Sasaki Y, Rothe T, Premkumar L, Takasu M, Crandall J, Dikkes P, Conner D, Rayudu P, Cheung W, Chen H, Lipton S, Nakanishi N. Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. Nature 1998, 393: 377-381. PMID: 9620802, DOI: 10.1038/30748.Peer-Reviewed Original ResearchConceptsNMDA receptorsReceptor subunit NR1Synaptic refinementSpine densityNMDA receptor subunit NR3ANMDA responsesNMDA subclassSmall unitary conductanceNMDAR activitySubunit NR1NMDAR subunitsCerebrocortical neuronsDendritic spinesSynaptic plasticityNR1 subunitMice resultsSingle-channel recordingsGenetic knockoutSynaptic elementsHeteromultimeric channelsNR1NR3AXenopus oocytesUnitary conductanceNMDA