1997
Agonist-induced closure of constitutively open γ-aminobutyric acid channels with mutated M2 domains
Pan Z, Zhang D, Zhang X, Lipton S. Agonist-induced closure of constitutively open γ-aminobutyric acid channels with mutated M2 domains. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 6490-6495. PMID: 9177245, PMCID: PMC21077, DOI: 10.1073/pnas.94.12.6490.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCloning, MolecularFemaleGABA AgonistsGABA AntagonistsGamma-Aminobutyric AcidIon Channel GatingIon ChannelsMacromolecular SubstancesMembrane PotentialsMolecular Sequence DataMutagenesis, Site-DirectedOocytesOrganophosphorus CompoundsPoint MutationRatsReceptors, GABAReceptors, GlycineReceptors, NicotinicRecombinant ProteinsSequence AlignmentSequence Homology, Amino AcidVirulence Factors, BordetellaXenopus laevisConceptsLigand-gated ion channelsChannel gatingIon channelsAmino acid residuesAminobutyric acid channelsSingle-point mutantsAbsence of ligandChannel pore regionStructure-function relationshipsPoint mutantsAcid channelImportant new insightsAllosteric transitionSubunit resultsAcid residuesM2 domainConstitutive currentReceptor proteinPore regionAgonist bindingAgonist regulationSubstituting alanineM2 regionSpontaneous channel openingChannel opening
1994
Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor
Sullivan J, Traynelis S, Chen H, Escobar W, Heinemann S, Lipton S. Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor. Neuron 1994, 13: 929-936. PMID: 7524561, DOI: 10.1016/0896-6273(94)90258-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCysteineDithiothreitolElectrophysiologyFemaleIon Channel GatingIon ChannelsMolecular Sequence DataMutagenesis, Site-DirectedN-MethylaspartateOocytesOxidation-ReductionPatch-Clamp TechniquesRatsReceptors, N-Methyl-D-AspartateRecombinant ProteinsSpermineStructure-Activity RelationshipXenopus