1995
Co-expression of AMPA/kainate receptor-operated channels with high and low Ca2+ permeability in single rat retinal ganglion cells
Zhang D, Sucher N, Lipton S. Co-expression of AMPA/kainate receptor-operated channels with high and low Ca2+ permeability in single rat retinal ganglion cells. Neuroscience 1995, 67: 177-188. PMID: 7477898, DOI: 10.1016/0306-4522(94)00627-h.Peer-Reviewed Original ResearchConceptsRat retinal ganglion cellsRetinal ganglion cellsD-aspartate receptorsReceptor-operated channelsGanglion cellsWhole-cell currentsPermeable AMPA/kainate channelsAMPA/kainate channelsLow Ca2Only permeant cationExtracellular solutionPatch-clamp techniqueSecond groupFirst groupKainate channelsFlop splice variantsPolymerase chain reactionGlutamate receptorsConcentrations of AMPAPattern of expressionReceptorsChain reactionSole charge carrierCurrent-voltage relationshipPredominant expression
1989
Calcium channels in solitary retinal ganglion cells from post‐natal rat.
Karschin A, Lipton S. Calcium channels in solitary retinal ganglion cells from post‐natal rat. The Journal Of Physiology 1989, 418: 379-396. PMID: 2559971, PMCID: PMC1189978, DOI: 10.1113/jphysiol.1989.sp017847.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsWhole-cell recordingsCalcium currentGanglion cellsOmega-conotoxin fraction GVIAT-type calcium currentL-type calcium currentDorsal root ganglion neuronesCell-attached patch recordingsDihydropyridine agonist Bay K8644Agonist Bay K8644Central mammalian neuronesPost-natal ratsSingle-channel patch-clamp techniquesPatch-clamp techniqueCell-attached recordingsWhole-cell currentsNeuronal membrane potentialEquimolar Ba2Reversible blockadeBay K8644T-currentsGanglion neuronesPharmacological agentsCalcium channelsGABA-activated single channel currents in outside-out membrane patches from rat retinal ganglion cells
Lipton S. GABA-activated single channel currents in outside-out membrane patches from rat retinal ganglion cells. Visual Neuroscience 1989, 3: 275-279. PMID: 2487107, DOI: 10.1017/s0952523800010026.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsGamma-aminobutyric acidGanglion cellsWhole-cell currentsMammalian retinal ganglion cellsRat retinal ganglion cellsLarge whole-cell currentsMammalian central nervous systemWhole-cell recordingsCentral nervous systemPatch-clamp methodInhibitory transmitterWhole-cell responsesNervous systemCell-free patchesNervous tissueGABAA channelsRapid rundownDesensitization kineticsSingle-channel recordingsChannel currentsSingle-channel currentsExcised patch configurationsSingle-channel eventsUnitary conductance
1987
Voltage‐dependent conductances of solitary ganglion cells dissociated from the rat retina.
Lipton S, Tauck D. Voltage‐dependent conductances of solitary ganglion cells dissociated from the rat retina. The Journal Of Physiology 1987, 385: 361-391. PMID: 2443669, PMCID: PMC1192350, DOI: 10.1113/jphysiol.1987.sp016497.Peer-Reviewed Original ResearchConceptsWhole-cell recordingsRetinal ganglion cellsGanglion cellsPatch pipetteMicroM TTXRat retinaAction potentialsMM TEASlow action potentialsPatch-clamp recordingsSingle-channel recordingsCentral mammalian neuronesConventional intracellular electrodesCurrent-clamp conditionsWhole-cell currentsVoltage-clamp experimentsIntracellular recordingsVoltage-clamp analysisPharmacological agentsExtracellular Ca2Inactivation time constantsMicroM Cd2Conventional intracellularElectrophysiological propertiesFast spikes