1994
Greater sensitivity of larger retinal ganglion cells to NMDA-mediated cell death
Dreyer E, Pan Z, Storm S, Lipton S. Greater sensitivity of larger retinal ganglion cells to NMDA-mediated cell death. Neuroreport 1994, 5: 629-631. PMID: 7912962, DOI: 10.1097/00001756-199401000-00024.Peer-Reviewed Original ResearchConceptsLarge retinal ganglion cellsRetinal ganglion cellsGanglion cellsGlutamate-mediated cell deathN-methyl-D-aspartate (NMDA) subtypeIntact rat eyesCell deathNeuronal lossGlutamate toxicityGlutamate receptorsRat eyesPattern of lossNMDAGlaucomaToxic effectsDeathCellsGlutamateTissue cultureGreater sensitivitySubtypesNeuronsSimilar fashionReceptors
1991
Calcium channel antagonists attenuate NMDA receptor-mediated neurotoxicity of retinal ganglion cells in culture
Sucher N, Lei S, Lipton S. Calcium channel antagonists attenuate NMDA receptor-mediated neurotoxicity of retinal ganglion cells in culture. Brain Research 1991, 551: 297-302. PMID: 1680525, DOI: 10.1016/0006-8993(91)90944-q.Peer-Reviewed Original ResearchConceptsCalcium channel antagonistsRetinal ganglion cellsChannel antagonistsGanglion cellsPostnatal rat retinal ganglion cellsNMDA receptor-operated channelsRat retinal ganglion cellsNMDA receptor-mediated neurotoxicityVoltage-dependent calcium channelsSelective NMDA antagonistDihydropyridine calcium channel antagonistReceptor-operated channelsVoltage-dependent Ca2Patch-clamp recordingsNMDA antagonistsNMDA receptorsSubsequent toxic effectsCalcium channelsExogenous glutamateRetinal culturesAntagonistL-typeEarly riseInjurious effectsToxic effects