2001
Structure and function of GABAC receptors: a comparison of native versus recombinant receptors
Zhang D, Pan Z, Awobuluyi M, Lipton S. Structure and function of GABAC receptors: a comparison of native versus recombinant receptors. Trends In Pharmacological Sciences 2001, 22: 121-132. PMID: 11239575, DOI: 10.1016/s0165-6147(00)01625-4.Peer-Reviewed Original ResearchConceptsRecombinant receptorsGABA receptorsIonotropic GABA receptorsRetinal signal processingInhibitory receptorsGABAC receptorsPharmacological profileBrain regionsSpecific drugsReceptorsNative receptorMajor molecular componentsUnique functional rolesFunctional roleMolecular determinantsSlow activationCompelling evidenceSubunit compositionMolecular basisRetina
2000
Redox modulation of recombinant human GABAA receptors
Pan Z, Zhang X, Lipton S. Redox modulation of recombinant human GABAA receptors. Neuroscience 2000, 98: 333-338. PMID: 10854765, DOI: 10.1016/s0306-4522(00)00114-7.Peer-Reviewed Original ResearchConceptsGABA receptorsRat retinal ganglion cellsRecombinant human GABAA receptorsRetinal ganglion cellsVoltage-clamp recordingsEffect of dithiothreitolLow GABA concentrationsTwo-electrode voltage-clamp recordingsRedox modulationHuman GABAA receptorsGanglion cellsXenopus oocyte expression systemGABAA receptorsModulatory effectsReceptor currentsOocyte expression systemReceptor responsesGABA concentrationPotentiationGABAReceptorsSubunit compositionHomomeric GABAAgent 5M3 domain