Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function
Ankarcrona M, Dypbukt J, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton S, Nicotera P. Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function. Neuron 1995, 15: 961-973. PMID: 7576644, DOI: 10.1016/0896-6273(95)90186-8.Peer-Reviewed Original ResearchConceptsIschemic brain injurySubpopulation of neuronsNeuronal cell deathPostsynaptic glutamate receptorsMitochondrial functionEarly necrotic phaseCerebellar granule cellsNeuronal deathBrain injuryGlutamate receptorsGranule cellsIntracellular Ca2Glutamate accumulationEarly necrosisNecrosisMitochondrial membrane potentialApoptotic nucleiIncubation mediumIntracellular debrisCell deathLow molecular weight fragmentsNecrotic phaseNeuronsApoptosisDeath