2009
Excitotoxicity in Neurodegenerative Disease
Haeberlein S, Lipton S. Excitotoxicity in Neurodegenerative Disease. 2009, 77-86. DOI: 10.1016/b978-008045046-9.00498-8.Peer-Reviewed Original ResearchHuman immunodeficiency virus-associated dementiaExcessive glutamate stimulationSpinal cord traumaMajor excitatory neurotransmitterAmyotrophic lateral sclerosisCord traumaExcitatory neurotransmitterGlutamate stimulationLateral sclerosisParkinson's diseaseTherapeutic interventionsAlzheimer's diseaseNeurodegenerative disordersDiseaseNeurodegenerative diseasesDownstream mechanismsHuntington's diseaseExcitotoxicityBrainSclerosisGlaucomaEpilepsyDementiaStrokeNeurotransmitters
2004
Excitotoxicity
Lipton S. Excitotoxicity. 2004, 291-313. DOI: 10.1002/3527603867.ch14.Peer-Reviewed Original Research
2001
Is tissue plasminogen activator a threat to neurons?
Traynelis S, Lipton S. Is tissue plasminogen activator a threat to neurons? Nature Medicine 2001, 7: 17-18. PMID: 11135603, DOI: 10.1038/83289.Peer-Reviewed Original ResearchPotential and Current Use of N-Methyl-D-Aspartate (NMDA) Receptor Antagonists in Diseases of Aging
Le D, Lipton S. Potential and Current Use of N-Methyl-D-Aspartate (NMDA) Receptor Antagonists in Diseases of Aging. Drugs & Aging 2001, 18: 717-724. PMID: 11735619, DOI: 10.2165/00002512-200118100-00001.Peer-Reviewed Original ResearchConceptsReceptor antagonistN-methyl-D-aspartate receptor antagonistN-methyl-D-aspartate (NMDA) receptor complexSafe NMDA antagonistMultiple clinical trialsNMDA receptor antagonistChronic painClinical trialsNMDA antagonistsGlutamate receptorsParkinson's diseaseNeurological disordersNeurodegenerative diseasesDiseaseAdverse effectsAntagonistReceptor complexCurrent useDrugsAdequate levelPainMemantineDysfunctionNitroglycerinStroke
1991
Glutathione prevents N -methyl-d-aspartate receptor-mediated neurotoxicity
Levy D, Sucher N, Lipton S. Glutathione prevents N -methyl-d-aspartate receptor-mediated neurotoxicity. Neuroreport 1991, 2: 345-347. PMID: 1832987, DOI: 10.1097/00001756-199106000-00011.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptor-mediated neurotoxicityNMDA receptor-channel complexSafe NMDA antagonistNMDA receptor activationPossible therapeutic modalityReceptor-channel complexNeuronal damageNMDA antagonistsNMDA receptorsTherapeutic modalitiesExcessive stimulationNeurodegenerative conditionsReceptor activationExtracellular mechanismsAntagonistPresent studyGlutathioneNeuroprotectionNeurotoxicityStrokeN-methylTraumaBrainReceptors