2024
Enzymatic and non-enzymatic transnitrosylation: “SCAN”ning the SNO-proteome
Nakamura T, Lipton S. Enzymatic and non-enzymatic transnitrosylation: “SCAN”ning the SNO-proteome. Molecular Cell 2024, 84: 191-193. PMID: 38242098, DOI: 10.1016/j.molcel.2023.12.018.Peer-Reviewed Original Research
2009
From Reactive Oxygen and Nitrogen Species to Therapy
McKercher S, Nakamura T, Lipton S. From Reactive Oxygen and Nitrogen Species to Therapy. 2009 DOI: 10.1002/9780470015902.a0021989.Peer-Reviewed Original ResearchReactive oxygen speciesProtein misfoldingS-nitrosylationE3 ubiquitin ligase ParkinUbiquitin ligase ParkinProtein disulfide isomeraseMisfolded protein aggregatesCritical cysteine thiolsS-nitrosylation reactionsExcessive reactive oxygen speciesNrf2 transcriptional pathwayProduction of ROSMisfolded proteinsProtein functionTranscriptional pathwaysCysteine thiolsProtein aggregatesMisfoldingReactive oxygenSpeciesPathological productionOxygen speciesGenetic mutationsNitrogen speciesNeurodegenerative diseases
2000
Redox modulation of the NMDA receptor
Choi Y, Lipton S. Redox modulation of the NMDA receptor. Cellular And Molecular Life Sciences 2000, 57: 1535-1541. PMID: 11092448, PMCID: PMC11147125, DOI: 10.1007/pl00000638.Peer-Reviewed Original ResearchConceptsRedox modulationCysteine residuesCritical cysteine residuesMultiple cysteine residuesDifferent NMDA receptor subunitsS-nitrosylationMolecular mechanismsMolecular determinantsNMDA receptor subunitsDistinct mechanismsReceptor subunitsPhysiological conditionsSubunitsNR2A subunitImportant mechanismN-methyl-D-aspartate receptorsResiduesNMDA receptorsRedox formsReceptorsCyclic GMPSpeciesMechanismForm of modulationRegulation
1999
Neuronal protection and destruction by NO
Lipton S. Neuronal protection and destruction by NO. Cell Death & Differentiation 1999, 6: 943-951. PMID: 10556970, DOI: 10.1038/sj.cdd.4400580.Peer-Reviewed Original ResearchConceptsS-nitrosylationCysteine residuesCaspase enzyme activityNeuronal apoptotic pathwayProtein functionCritical thiol groupsApoptotic pathwayMolecular switchReactive thiol groupsCritical thiolsN-methyl-D-aspartate receptor activityDisulfide bondsRedox stateThiol groupsDeath of neuronsSpeciesDifferent redox statesEnzyme activityDistinct chemical reactivityCaspasesPhysiological conditionsBiological activityActive siteResiduesReceptor activity
1998
NO-NMDA Receptor Interactions: A Neuromolecular Approach to Novel Therapeutics
Lipton S, Choi Y, Sucher N, Chen H. NO-NMDA Receptor Interactions: A Neuromolecular Approach to Novel Therapeutics. Ernst Schering Foundation Symposium Proceedings 1998, 95-108. DOI: 10.1007/978-3-662-03596-2_5.Peer-Reviewed Original ResearchRedox-related speciesFree sulfhydryl groupsSufficient redox potentialRedox modulationSulfhydryl groupsProtein cysteine residuesEndogenous redox agentsOrganic synthesisSingle sulfhydryl groupRedox potentialProtein functionRedox agentsCysteine residuesDistinctive chemistryNO groupCell typesDisulfide bondsGroup donorBiological systemsReceptor interactionDifferent biological effectsSpeciesOxygen speciesNovel therapeuticsEndogenous sources