Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons
Budd S, Tenneti L, Lishnak T, Lipton S. Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 6161-6166. PMID: 10811898, PMCID: PMC18575, DOI: 10.1073/pnas.100121097.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsApoptosisBongkrekic AcidCaspase 3Caspase 8Caspase 9CaspasesCerebral CortexCytochrome c GroupEnzyme ActivationEnzyme InhibitorsIntracellular MembranesMitochondriaMitochondrial ADP, ATP TranslocasesNerve Tissue ProteinsNeuronsPermeabilityProtein Kinase InhibitorsReceptors, N-Methyl-D-AspartateStaurosporineConceptsAdenine nucleotide translocatorBongkrekic acidCaspase-3 activationMitochondrial adenine nucleotide translocatorCyt cReceptor-mediated apoptosisApoptotic signaling pathwaysMitochondrial permeability transition poreMitochondrial membrane potentialPermeability transition poreStaurosporine-induced activationCellular ATP contentStaurosporine resultsPutative componentsCerebrocortical neuronsNucleotide translocatorCaspase activityCaspase-8Signaling pathwaysTransition poreMitochondrial dysfunctionCytochrome cDistinct pathwaysCultured cerebrocortical neuronsApoptosis