2000
Chapter 29 Role of Nitric Oxide in Neuronal Protection versus Apoptosis
Lipton S. Chapter 29 Role of Nitric Oxide in Neuronal Protection versus Apoptosis. 2000, 453-464. DOI: 10.1016/b978-012370420-7/50030-7.Peer-Reviewed Original ResearchDifferent chemical statesPossible chemical reactionsRedox reactionsChapter 29 RoleChemical stateRelated reactionsFurther oxidationDistinct reactivityActive siteChemical reactionsCysteine residue presentThiol groupsOxide groupsAdditional electronBiological activityNitroxyl anionS-nitrosylationReactionRedox stateCaspase enzymesCritical thiolsCysteine residuesCritical cysteine residuesResidue presentAnions
1998
Chapter 6 Redox modulation of the NMDA receptor by NO-related species
Lipton S, Rayudu P, Choi Y, Sucher N, Chen H. Chapter 6 Redox modulation of the NMDA receptor by NO-related species. Progress In Brain Research 1998, 118: 73-82. PMID: 9932435, DOI: 10.1016/s0079-6123(08)63201-x.Peer-Reviewed Original ResearchConceptsChemical reactionsMechanism of reactionRedox stateReactive thiol groupsCatalytic amountFurther oxidationThiol groupsElectron acceptorPreferred reactionReceptor sulfhydryl groupsChemical evidenceSinglet stateNO groupBiological activityMolecular switchReactionThiolsDisulfide bondsSulfhydryl groupsCritical thiolsO2NOS-nitrosylationRedox modulationBonds
1993
A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds
Lipton S, Choi Y, Pan Z, Lei S, Chen H, Sucher N, Loscalzo J, Singel D, Stamler J. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 1993, 364: 626-632. PMID: 8394509, DOI: 10.1038/364626a0.Peer-Reviewed Original ResearchConceptsNitrogen monoxideRedox-based mechanismComplex redox chemistryS-nitrosylationRedox milieuRedox versatilityRedox chemistryAlternative redox statesNitrosonium ionReceptor thiolsRedox stateNeurotoxic speciesNMDA receptor activityReceptor activationNMDA receptor activationReactionFormation of peroxynitriteThiols