2004
HIV-1 associated dementia
Kaul M, Lipton S. HIV-1 associated dementia. 2004, 305-315. DOI: 10.1007/978-1-4419-8959-8_17.Peer-Reviewed Original ResearchHuman immunodeficiency virus-1HIV-1 associated dementiaAssociated dementiaNMDA receptor-mediated excitotoxicityApplicable therapeutic interventionReceptor-mediated excitotoxicityImmunodeficiency virus-1Cytotoxic free radicalsNeuronal injuryInflammatory factorsChemokine receptorsTherapeutic interventionsExcessive influxDownstream mechanismsDementiaVirus 1Lines of evidenceDevastating consequencesFree radicalsExcitotoxicityNeuropathologyProtein kinaseTranscription factorsInjuryInfection
2000
Role of p38 Mitogen-Activated Protein Kinase in Axotomy-Induced Apoptosis of Rat Retinal Ganglion Cells
Kikuchi M, Tenneti L, Lipton S. Role of p38 Mitogen-Activated Protein Kinase in Axotomy-Induced Apoptosis of Rat Retinal Ganglion Cells. Journal Of Neuroscience 2000, 20: 5037-5044. PMID: 10864961, PMCID: PMC6772303, DOI: 10.1523/jneurosci.20-13-05037.2000.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisAxonal TransportAxotomyCell NucleusCell SurvivalDizocilpine MaleateEnzyme InhibitorsFluorescent DyesImidazolesKineticsMaleMitogen-Activated Protein KinasesNeuroprotective AgentsOptic NerveP38 Mitogen-Activated Protein KinasesPhosphorylationPyridinesRatsRats, Long-EvansRetinal Ganglion CellsSignal TransductionStilbamidinesTime FactorsConceptsRetinal ganglion cellsProtein kinaseP38 Mitogen-Activated Protein KinaseMitogen-Activated Protein KinaseMAP kinase activationIntracellular signal transductionRole of p38P38 MAP kinase activationApoptotic cell deathDose-dependent mannerP38 MAP kinase inhibitorMAP kinase inhibitorRGC apoptosisOptic nerveGanglion cellsSignal transductionNMDA receptorsAxotomy-induced apoptosisApoptotic signalingKinase activationP38 inhibitorRat retinal ganglion cellsCell deathCell typesOptic nerve trauma