Regulation of nitric oxide synthase activity in human immunodeficiency virus type 1 (HIV-1)-infected monocytes: implications for HIV-associated neurological disease.
Bukrinsky M, Nottet H, Schmidtmayerova H, Dubrovsky L, Flanagan C, Mullins M, Lipton S, Gendelman H. Regulation of nitric oxide synthase activity in human immunodeficiency virus type 1 (HIV-1)-infected monocytes: implications for HIV-associated neurological disease. Journal Of Experimental Medicine 1995, 181: 735-745. PMID: 7530762, PMCID: PMC2191885, DOI: 10.1084/jem.181.2.735.Peer-Reviewed Original ResearchConceptsEffector cell functionInducible NO synthaseBrain tissueAIDS patientsHIV-1Human immunodeficiency virus (HIV) persistenceHuman immunodeficiency virus type 1Human monocytesNitric oxide synthase activityImmunodeficiency virus type 1HIV-macrophage interactionsPediatric AIDS patientsHIV-1 diseaseCell functionHIV-1 infectionMacrophage antigen presentationExpression of NOSOxide synthase activityVirus-infected macrophagesPostmortem brain tissueVirus type 1Productive viral replicationCultured human monocytesHIV encephalitisHIV replication