VIP-mediated increase in cAMP prevents tetrodotoxin-induced retinal ganglion cell death in vitro
Kaiser P, Lipton S. VIP-mediated increase in cAMP prevents tetrodotoxin-induced retinal ganglion cell death in vitro. Neuron 1990, 5: 373-381. PMID: 2169272, DOI: 10.1016/0896-6273(90)90173-d.Peer-Reviewed Original ResearchConceptsVasoactive intestinal peptideNatural cell deathRGC survivalRetinal ganglion cell deathRetinal ganglion cell neuronsCell deathGanglion cell deathGanglion cell neuronsElectrical blockadePHI-27VIP10-28Intestinal peptideAfferent influencesNeurotrophic effectsNeonatal ratsTetrodotoxin blockadeVIP stimulationRetinal culturesCell neuronsIntact retinaAdenylate cyclaseNormal cell deathElectrical activityDeathRGCs