Memantine prevents HIV coat protein-induced neuronal injury in vitro.
Lipton S. Memantine prevents HIV coat protein-induced neuronal injury in vitro. Neurology 1992, 42: 1403-5. PMID: 1620355, DOI: 10.1212/wnl.42.7.1403.Peer-Reviewed Original ResearchConceptsNeuronal injuryNeuronal damageHIV-1 coat protein gp120Cognitive/motor complexRat retinal ganglion cellsN-methyl-D-aspartate receptorsHuman immunodeficiency virusPossible protective effectNMDA receptor-operated ion channelsRetinal ganglion cellsReceptor-operated ion channelsMicroM memantineNeurologic deficitsImmunodeficiency virusGanglion cellsNMDA antagonistsProtective effectProtein gp120Therapeutic potentialGp120InjuryMemantineMotor complexConcurrent activationIon channels