1998
NEURONAL INJURY ASSOCIATED WITH HIV-1: Approaches to Treatment
Lipton S. NEURONAL INJURY ASSOCIATED WITH HIV-1: Approaches to Treatment. The Annual Review Of Pharmacology And Toxicology 1998, 38: 159-177. PMID: 9597152, DOI: 10.1146/annurev.pharmtox.38.1.159.Peer-Reviewed Original ResearchConceptsNeuronal injuryNeuronal damageHIV-1-associated cognitive/motor complexN-methyl-D-aspartate (NMDA) receptor-operated channelsCognitive/motor complexAIDS dementia complexHIV-1 resultsHIV-1 infectionExistence of HIVBrains of patientsReceptor-operated channelsFuture pharmacological interventionsFinal common pathwayPlatelet-activating factorFree radicalsAIDS dementiaReactive astrocytesDementia complexCognitive dysfunctionNMDA antagonistsExcessive activationNeuronal susceptibilityPharmacological interventionsHIV-1Excessive influx
1996
Similarity of Neuronal Cell Injury and Death in AIDS Dementia and Focal Cerebral Ischemia: Potential Treatment with NMDA Open‐Channel Blockers and Nitric Oxide‐Related Species
Lipton S. Similarity of Neuronal Cell Injury and Death in AIDS Dementia and Focal Cerebral Ischemia: Potential Treatment with NMDA Open‐Channel Blockers and Nitric Oxide‐Related Species. Brain Pathology 1996, 6: 507-517. PMID: 8944320, DOI: 10.1111/j.1750-3639.1996.tb00879.x.Peer-Reviewed Original ResearchConceptsFocal cerebral ischemiaNeuronal cell deathAIDS dementiaNeuronal injuryCerebral ischemiaNeuronal damageCell injuryHIV-1-associated cognitive/motor complexN-methyl-D-aspartate (NMDA) receptor-operated channelsCognitive/motor complexNMDA open-channel blockersHIV-1 envelope protein gp120Cell deathHIV-1 resultsExistence of HIVNeuronal cell injuryReceptor-operated channelsFuture pharmacological interventionsFinal common pathwayEnvelope protein gp120Platelet-activating factorFree radicalsOpen channel blockerAIDS brainsIschemic coreAIDS Dementia as a Form of Excitotoxicity: Potential Therapy with NMDA Open-Channel Blockers and Redox Congeners of Nitric Oxide
Lipton S. AIDS Dementia as a Form of Excitotoxicity: Potential Therapy with NMDA Open-Channel Blockers and Redox Congeners of Nitric Oxide. Gwumc Department Of Biochemistry And Molecular Biology Annual Spring Symposia 1996, 341-356. DOI: 10.1007/978-1-4899-0209-2_41.Peer-Reviewed Original ResearchRedox modulatory siteNMDA receptorsOpen channel blockerNeuronal injuryNeuronal damageN-methyl-D-aspartate (NMDA) receptor-operated channelsModulatory siteNMDA open-channel blockersNitric oxideHIV-1 envelope protein gp120Forms of excitotoxicityAIDS dementia complexHIV-1 resultsExcitatory amino acidsMacrophages/microgliaExistence of HIVReceptor-operated channelsFuture pharmacological interventionsFinal common pathwayAmyotrophic lateral sclerosisEnvelope protein gp120Platelet-activating factorReceptor/channel complexNormal neuronal functionNMDA receptor/channel complex
1994
AIDS‐Related Dementia and Calcium Homeostasisa
LIPTON S. AIDS‐Related Dementia and Calcium Homeostasisa. Annals Of The New York Academy Of Sciences 1994, 747: 205-224. PMID: 7847672, DOI: 10.1111/j.1749-6632.1994.tb44411.x.Peer-Reviewed Original ResearchConceptsNeuronal injuryN-methyl-D-aspartate (NMDA) receptor-operated channelsHuman immunodeficiency virus type 1Arachidonic acidHIV-1 envelope protein gp120Immunodeficiency virus type 1Existence of HIVDeath of neuronsBrains of patientsCalcium channel antagonistsVoltage-dependent Ca2Interleukin-1 betaReceptor-operated channelsFuture pharmacological interventionsFinal common pathwayAmyotrophic lateral sclerosisHalf of childrenEnvelope protein gp120Platelet-activating factorThird of adultsVirus type 1Dysfunction of cognitionGamma interferon stimulationNeuropathic painAIDS dementiaCa2+, N-Methyl-d-Aspartate Receptors, and Aids-Related Neuronal Injury
Lipton S. Ca2+, N-Methyl-d-Aspartate Receptors, and Aids-Related Neuronal Injury. International Review Of Neurobiology 1994, 36: 1-27. PMID: 7822116, DOI: 10.1016/s0074-7742(08)60301-3.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate (NMDA) receptor-operated channelsN-methyl-D-aspartate receptorsHIV-1 envelope protein gp120Existence of HIVVoltage-dependent Ca2Receptor-operated channelsFuture pharmacological interventionsFinal common pathwayAmyotrophic lateral sclerosisEnvelope protein gp120Demise of neuronsNeuronal injuryAIDS patientsNeuronal susceptibilityPharmacological interventionsProtein gp120Lateral sclerosisParkinson's diseaseMacrophage productionInduces releaseHIVNitric oxideNeurodegenerative diseasesDiseaseHuntington's disease