1991
Calcium channel antagonists and human immunodeficiency virus coat protein–mediated neuronal injury
Lipton S. Calcium channel antagonists and human immunodeficiency virus coat protein–mediated neuronal injury. Annals Of Neurology 1991, 30: 110-114. PMID: 1656845, DOI: 10.1002/ana.410300121.Peer-Reviewed Original ResearchConceptsVoltage-dependent calcium channelsCalcium channel antagonistsNeuronal injuryChannel antagonistsCalcium channelsHuman immunodeficiency virus type 1 (HIV-1) envelope proteinImmunodeficiency syndrome dementia complexRat retinal ganglion cellsSubsequent neuronal injuryNeuronal calcium channelsRetinal ganglion cellsVoltage-dependent Ca2Mammalian central neuronsChannel antagonist drugsNeuronal damageDementia complexMaximal doseCentral neuronsGanglion cellsDihydropyridine classIntracellular calciumAntagonist drugsElectrophysiological studiesLow micromolar concentrationsGp120
1990
Redox modulation of NMDA receptor-mediated toxicity in mammalian central neurons
Levy D, Sucher N, Lipton S. Redox modulation of NMDA receptor-mediated toxicity in mammalian central neurons. Neuroscience Letters 1990, 110: 291-296. PMID: 1970145, DOI: 10.1016/0304-3940(90)90862-4.Peer-Reviewed Original ResearchConceptsCentral neuronsNMDA receptorsN-methyl-D-aspartate (NMDA) subtypeNMDA receptor-mediated toxicityAmyotrophic lateral sclerosis-ParkinsonismAcute neurological injuryGlutamate-induced deathNMDA receptor sitesSurvival of neuronsRetinal ganglion cellsMammalian central neuronsReceptor-operated channelsChronic degenerative diseasesReceptor-mediated toxicityHypoxia-ischemiaNMDA neurotoxicityDementia complexNeurological injurySimilar pathogenesisGanglion cellsGlutamate receptorsEnhanced killingRedox modulationDegenerative diseasesHuntington's disease
1988
Acidic fibroblast growth factor enhances regeneration of processes by postnatal mammalian retinal ganglion cells in culture.
Lipton S, Wagner J, Madison R, D'Amore P. Acidic fibroblast growth factor enhances regeneration of processes by postnatal mammalian retinal ganglion cells in culture. Proceedings Of The National Academy Of Sciences Of The United States Of America 1988, 85: 2388-2392. PMID: 3353388, PMCID: PMC279998, DOI: 10.1073/pnas.85.7.2388.Peer-Reviewed Original ResearchConceptsRat retinal ganglion cellsBasic fibroblast growth factorAcidic fibroblast growth factorRetinal ganglion cellsFibroblast growth factorGlial cellsGrowth factorProcess outgrowthGanglion cellsPostnatal rat retinal ganglion cellsMammalian retinal ganglion cellsOutgrowth of processesGlial fibrillary acidic proteinEffect of aFGFMammalian central nervous systemMammalian central neuronsRegeneration of processesFibrillary acidic proteinCentral nervous systemPeptide growth factorsRGC survivalHumoral effectsHeparin-like moleculesCentral neuronsAddition of heparin
1987
Bursting of calcium-activated cation-selective channels is associated with neurite regeneration in a mammalian central neuron
Lipton S. Bursting of calcium-activated cation-selective channels is associated with neurite regeneration in a mammalian central neuron. Neuroscience Letters 1987, 82: 21-28. PMID: 2447529, DOI: 10.1016/0304-3940(87)90165-0.Peer-Reviewed Original ResearchConceptsPostnatal rat retinal ganglion cellsNeurite regenerationRat retinal ganglion cellsMammalian central nervous systemRetinal ganglion cellsMammalian central neuronsCentral nervous systemPatch-clamp techniqueCell-attached patchesGanglion cellsCentral neuronsNervous systemIntracellular Ca2Internal calciumCation-selective channelsSingle-channel currentsNeuronsProlonged periodCells