2001
Pathways to neuronal injury and apoptosis in HIV-associated dementia
Kaul M, Garden G, Lipton S. Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature 2001, 410: 988-994. PMID: 11309629, DOI: 10.1038/35073667.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus-1Neuronal injuryRelease of macrophageImmunodeficiency virus-1Direct injuryTherapeutic interventionsAlarming occurrenceNeurodegenerative diseasesInjuryVirus 1NeuronsDementiaViral proteinsMacrophagesFree radicalsApoptosisToxinPathwayExcitotoxicityMicrogliaHIVDiseaseBrain
1995
The Coat Protein gp120 of HIV‐1 Inhibits Astrocyte Uptake of Excitatory Amino Acids via Macrophage Arachidonic Acid
Dreyer E, Lipton S. The Coat Protein gp120 of HIV‐1 Inhibits Astrocyte Uptake of Excitatory Amino Acids via Macrophage Arachidonic Acid. European Journal Of Neuroscience 1995, 7: 2502-2507. PMID: 8845955, DOI: 10.1111/j.1460-9568.1995.tb01048.x.Peer-Reviewed Original ResearchConceptsExcitatory amino acidsAmino acidsAstrocyte uptakeNeuronal damageProtein gp120Excitatory amino acid uptakeAmino acid uptakeN-methyl-D-aspartate receptorsArachidonic acidCentral mammalian neuronsMammalian neuronsReleases arachidonic acidNeuronal injuryBrain macrophagesImmunodeficiency syndromeNeurological dysfunctionAcid uptakeExcess glutamateGp120MacrophagesAstrocytesNeuronsInitial activationPresent dataUptake
1994
The neuropathogenesis of HIV-1 infection
Gendelman H, Lipton S, Tardieu M, Bukrinsky M, Nottet H. The neuropathogenesis of HIV-1 infection. Journal Of Leukocyte Biology 1994, 56: 389-398. PMID: 8083614, DOI: 10.1002/jlb.56.3.389.Peer-Reviewed Original ResearchConceptsCentral nervous system infectionHIV-1-infected macrophagesBrain tissue pathologyNervous system infectionHIV-1 infectionProductive viral replicationVirus-infected cellsHIV neuropathogenesisMononuclear phagocyte lineageSystem infectionHIV infectionNeuronal damageBrain macrophagesCNS diseaseGlial proliferationGiant cellsTissue pathologyViral replicationSoluble factorsNeurotoxic activityInfectionMacrophagesPhagocyte lineageHIVNeuropathogenesis
1993
Human immunodefciency virus‐infected macrophages, gp120, and N‐methyl‐D‐ aspartate receptor‐mediated new‐otoxicity
Lipton S. Human immunodefciency virus‐infected macrophages, gp120, and N‐methyl‐D‐ aspartate receptor‐mediated new‐otoxicity. Annals Of Neurology 1993, 33: 227-228. PMID: 8434889, DOI: 10.1002/ana.410330218.Peer-Reviewed Original Research
1992
Requirement for macrophages in neuronal injury induced by HIV envelope protein gp120
Lipton S. Requirement for macrophages in neuronal injury induced by HIV envelope protein gp120. Neuroreport 1992, 3: 913-915. PMID: 1421098, DOI: 10.1097/00001756-199210000-00023.Peer-Reviewed Original ResearchConceptsHIV envelope protein gp120Retinal ganglion cellsEnvelope protein gp120Neuronal injuryGanglion cellsGlial cellsProtein gp120N-methyl-D-aspartate antagonistsMixed neuronal-glial culturesRetinal ganglion cell neuronsNeuronal-glial culturesGanglion cell neuronsActivation of macrophagesPresence of macrophagesPM gp120Like damageGlial culturesCell neuronsGp120Early increaseFree calciumPostnatal retinaMacrophagesInjurious effectsNeurons