Role of p38 Mitogen-Activated Protein Kinase in Axotomy-Induced Apoptosis of Rat Retinal Ganglion Cells
Kikuchi M, Tenneti L, Lipton S. Role of p38 Mitogen-Activated Protein Kinase in Axotomy-Induced Apoptosis of Rat Retinal Ganglion Cells. Journal Of Neuroscience 2000, 20: 5037-5044. PMID: 10864961, PMCID: PMC6772303, DOI: 10.1523/jneurosci.20-13-05037.2000.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisAxonal TransportAxotomyCell NucleusCell SurvivalDizocilpine MaleateEnzyme InhibitorsFluorescent DyesImidazolesKineticsMaleMitogen-Activated Protein KinasesNeuroprotective AgentsOptic NerveP38 Mitogen-Activated Protein KinasesPhosphorylationPyridinesRatsRats, Long-EvansRetinal Ganglion CellsSignal TransductionStilbamidinesTime FactorsConceptsRetinal ganglion cellsProtein kinaseP38 Mitogen-Activated Protein KinaseMitogen-Activated Protein KinaseMAP kinase activationIntracellular signal transductionRole of p38P38 MAP kinase activationApoptotic cell deathDose-dependent mannerP38 MAP kinase inhibitorMAP kinase inhibitorRGC apoptosisOptic nerveGanglion cellsSignal transductionNMDA receptorsAxotomy-induced apoptosisApoptotic signalingKinase activationP38 inhibitorRat retinal ganglion cellsCell deathCell typesOptic nerve trauma