2007
CHAPTER 25 Functional Characterization of Neurons
McKerchner S, Talantova M, Lipton S. CHAPTER 25 Functional Characterization of Neurons. 2007, 373-386. DOI: 10.1016/b978-012370465-8/50030-2.Peer-Reviewed Original ResearchCentral nervous systemAmyotrophic lateral sclerosisJuvenile-onset diseaseStem cell therapyNeuronal damageCurative treatmentElectrophysiological criteriaMacular degenerationLysosomal storage diseaseParkinson's diseaseLateral sclerosisOnset diseaseNervous systemAlzheimer's diseaseDiseaseCell therapySuch pathologyHuntington's diseaseStorage diseaseEarly childhoodTotal absenceLabeling cellsSclerosisTherapyInjury
2004
HIV-1 associated dementia
Kaul M, Lipton S. HIV-1 associated dementia. 2004, 305-315. DOI: 10.1007/978-1-4419-8959-8_17.Peer-Reviewed Original ResearchHuman immunodeficiency virus-1HIV-1 associated dementiaAssociated dementiaNMDA receptor-mediated excitotoxicityApplicable therapeutic interventionReceptor-mediated excitotoxicityImmunodeficiency virus-1Cytotoxic free radicalsNeuronal injuryInflammatory factorsChemokine receptorsTherapeutic interventionsExcessive influxDownstream mechanismsDementiaVirus 1Lines of evidenceDevastating consequencesFree radicalsExcitotoxicityNeuropathologyProtein kinaseTranscription factorsInjuryInfection
2001
Pathways to neuronal injury and apoptosis in HIV-associated dementia
Kaul M, Garden G, Lipton S. Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature 2001, 410: 988-994. PMID: 11309629, DOI: 10.1038/35073667.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus-1Neuronal injuryRelease of macrophageImmunodeficiency virus-1Direct injuryTherapeutic interventionsAlarming occurrenceNeurodegenerative diseasesInjuryVirus 1NeuronsDementiaViral proteinsMacrophagesFree radicalsApoptosisToxinPathwayExcitotoxicityMicrogliaHIVDiseaseBrain
1999
Excitotoxins in Neuronal Apoptosis and Necrosis
Nicotera P, Lipton S. Excitotoxins in Neuronal Apoptosis and Necrosis. Cerebrovascular And Brain Metabolism Reviews 1999, 19: 583-591. PMID: 10366188, DOI: 10.1097/00004647-199906000-00001.Peer-Reviewed Original ResearchConceptsCommon histopathologic featuresLocal inflammatory reactionProgression of diseaseCell deathNeuronal injuryNeuronal lossHistopathologic featuresNeuronal demiseNeuropathologic conditionsInflammatory reactionNeurotoxic injuryNeuronal apoptosisPathologic conditionsNecrosisCell destructionPrevention of apoptosisNuclear pyknosisNeurodegenerative diseasesType of deathInjuryCell swellingGeneralized disruptionDeathApoptosisPrevalence
1998
Neuroprotective versus neurodestructive effects of NO‐related species
Lipton S, Choi Y, Sucher N, Chen H. Neuroprotective versus neurodestructive effects of NO‐related species. BioFactors 1998, 8: 33-40. PMID: 9699006, DOI: 10.1002/biof.5520080107.Peer-Reviewed Original ResearchConceptsNMDA receptorsCentral nervous systemNMDA receptor subunitsNeuronal injuryNeurodestructive effectsNervous systemRedox modulationReceptor subunitsNitric oxideExcessive Ca2Protective actionChannel activitySuperoxide anionNO groupReceptorsS-nitrosylationGroupDiverse tissuesNeuroprotectionInjuryBrain
1997
A682 Mice Deficient In Mac-1, A beta sub 2 Integrin, Are Less Susceptible To Cerebral Ischemia-Reperfusion Injury
Soriano S, Coxon A, Wang Y, Lipton S, Hickey P, Mayadas T. A682 Mice Deficient In Mac-1, A beta sub 2 Integrin, Are Less Susceptible To Cerebral Ischemia-Reperfusion Injury. Anesthesiology 1997, 87: 682a. DOI: 10.1097/00000542-199709001-00682.Peer-Reviewed Original Research
1996
Neuronal apoptosis versus necrosis induced by glutamate or free radicals
Nicotera P, Ankarcrona M, Bonfoco E, Orrenius S, Lipton S. Neuronal apoptosis versus necrosis induced by glutamate or free radicals. Apoptosis 1996, 1: 5-10. DOI: 10.1007/bf00142073.Peer-Reviewed Original ResearchMajor excitatory neurotransmitterCentral nervous systemFailure of neuronsFree radicalsNeuronal cell culturesNeuronal injuryExcitatory neurotransmitterNeuronal apoptosisNervous systemApoptotic death programNitric oxideInsultInjuryCell deathDeath programNeuronsGlutamateCell culturesApoptosisExcitotoxinsIschemiaEnergy depletionNecrosisNeurotransmittersProgression
1992
Memantine prevents HIV coat protein-induced neuronal injury in vitro.
Lipton S. Memantine prevents HIV coat protein-induced neuronal injury in vitro. Neurology 1992, 42: 1403-5. PMID: 1620355, DOI: 10.1212/wnl.42.7.1403.Peer-Reviewed Original ResearchConceptsNeuronal injuryNeuronal damageHIV-1 coat protein gp120Cognitive/motor complexRat retinal ganglion cellsN-methyl-D-aspartate receptorsHuman immunodeficiency virusPossible protective effectNMDA receptor-operated ion channelsRetinal ganglion cellsReceptor-operated ion channelsMicroM memantineNeurologic deficitsImmunodeficiency virusGanglion cellsNMDA antagonistsProtective effectProtein gp120Therapeutic potentialGp120InjuryMemantineMotor complexConcurrent activationIon channelsModels of neuronal injury in AIDS: another role for the NMDA receptor?
Lipton S. Models of neuronal injury in AIDS: another role for the NMDA receptor? Trends In Neurosciences 1992, 15: 75-79. PMID: 1373919, DOI: 10.1016/0166-2236(92)90013-x.Peer-Reviewed Original ResearchConceptsNMDA receptor-operated channelsExistence of HIVVoltage-dependent Ca2Receptor-operated channelsFuture pharmacological interventionsFinal common pathwayDysfunction of cognitionDemise of neuronsNeuronal injuryNeurological manifestationsNeuronal damageImmunodeficiency syndromeAIDS patientsNMDA receptorsNeuronal susceptibilityPharmacological interventionsType 1 resultsCommon pathwayNeuronsPatientsInjuryTwo-thirdsHIVDysfunctionEpilepsy
1991
Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity
Lipton S, Sucher N, Kaiser P, Dreyer E. Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity. Neuron 1991, 7: 111-118. PMID: 1676893, DOI: 10.1016/0896-6273(91)90079-f.Peer-Reviewed Original ResearchConceptsNMDA receptor-mediated neurotoxicityHIV-1 coat protein gp120Whole-cell patch-clamp recordingsHIV coat proteinRat retinal culturesSubsequent neuronal damagePatch-clamp recordingsGlutamate pyruvate transaminaseNeuronal injuryNeuronal damageEndogenous glutamateGanglion cellsNMDA antagonistsProtein gp120Low picomolar concentrationsRetinal culturesGp120NeurotoxicityComplete protectionMinute increasePicomolar concentrationsGlutamateInjuryAntagonistTransaminase
1990
Comparison of delayed administration of competitive and uncompetitive antagonists in preventing NMDA receptor-mediated neuronal death.
Levy D, Lipton S. Comparison of delayed administration of competitive and uncompetitive antagonists in preventing NMDA receptor-mediated neuronal death. Neurology 1990, 40: 852-5. PMID: 1970428, DOI: 10.1212/wnl.40.5.852.Peer-Reviewed Original ResearchConceptsMK-801Uncompetitive antagonistCompetitive antagonistNMDA receptor-mediated neuronal deathN-methyl-D-aspartate receptorsRetinal ganglion cell neuronsStudies of excitotoxicityGanglion cell neuronsGlutamate-induced injuryNeuronal cell deathUncompetitive NMDA antagonistsHypoxia-ischemiaNeurologic injuryProtective dosesNeuronal deathCentral neuronsInitial insultNMDA antagonistsProtective effectCell neuronsAntagonistMinutes of exposureToxic damageInjuryCell death