2009
Matrix Metalloproteinases in Cerebral Hypoxia-Ischemia
Gu Z, Cui J, Lipton S. Matrix Metalloproteinases in Cerebral Hypoxia-Ischemia. Contemporary Clinical Neuroscience 2009, 225-238. DOI: 10.1007/978-1-60327-579-8_11.Peer-Reviewed Original ResearchNeuronal nitric oxide synthaseAcute cerebral ischemiaCerebral ischemiaMMP-9Neuronal apoptosisCerebral ischemia/reperfusionTransient focal cerebral ischemiaAcute stroke patientsCerebral hypoxia-ischemiaHypoxic-ischemic insultFocal cerebral ischemiaFuture clinical trialsIschemia/reperfusionNitric oxide synthaseMMP-9 activityMMP-2/9 inhibitorNeuronal cell deathShort-term therapyActivation of MMPsS-nitrosylationSignificant therapeutic potentialHypoxia-ischemiaNeuronal injuryIschemic damageStroke patients
1990
Comparison of delayed administration of competitive and uncompetitive antagonists in preventing NMDA receptor-mediated neuronal death.
Levy D, Lipton S. Comparison of delayed administration of competitive and uncompetitive antagonists in preventing NMDA receptor-mediated neuronal death. Neurology 1990, 40: 852-5. PMID: 1970428, DOI: 10.1212/wnl.40.5.852.Peer-Reviewed Original ResearchConceptsMK-801Uncompetitive antagonistCompetitive antagonistNMDA receptor-mediated neuronal deathN-methyl-D-aspartate receptorsRetinal ganglion cell neuronsStudies of excitotoxicityGanglion cell neuronsGlutamate-induced injuryNeuronal cell deathUncompetitive NMDA antagonistsHypoxia-ischemiaNeurologic injuryProtective dosesNeuronal deathCentral neuronsInitial insultNMDA antagonistsProtective effectCell neuronsAntagonistMinutes of exposureToxic damageInjuryCell deathRedox modulation of NMDA receptor-mediated toxicity in mammalian central neurons
Levy D, Sucher N, Lipton S. Redox modulation of NMDA receptor-mediated toxicity in mammalian central neurons. Neuroscience Letters 1990, 110: 291-296. PMID: 1970145, DOI: 10.1016/0304-3940(90)90862-4.Peer-Reviewed Original ResearchConceptsCentral neuronsNMDA receptorsN-methyl-D-aspartate (NMDA) subtypeNMDA receptor-mediated toxicityAmyotrophic lateral sclerosis-ParkinsonismAcute neurological injuryGlutamate-induced deathNMDA receptor sitesSurvival of neuronsRetinal ganglion cellsMammalian central neuronsReceptor-operated channelsChronic degenerative diseasesReceptor-mediated toxicityHypoxia-ischemiaNMDA neurotoxicityDementia complexNeurological injurySimilar pathogenesisGanglion cellsGlutamate receptorsEnhanced killingRedox modulationDegenerative diseasesHuntington's disease