1998
Synergistic Activation of theN-Methyl-d-aspartate Receptor Subunit 1 Promoter by Myocyte Enhancer Factor 2C and Sp1*
Krainc D, Bai G, Okamoto S, Carles M, Kusiak J, Brent R, Lipton S. Synergistic Activation of theN-Methyl-d-aspartate Receptor Subunit 1 Promoter by Myocyte Enhancer Factor 2C and Sp1*. Journal Of Biological Chemistry 1998, 273: 26218-26224. PMID: 9748305, DOI: 10.1074/jbc.273.40.26218.Peer-Reviewed Original ResearchMeSH KeywordsBinding SitesCell LineDNA-Binding ProteinsEpidermal Growth FactorFibroblast Growth Factor 2Gene Expression Regulation, DevelopmentalMEF2 Transcription FactorsMyogenic Regulatory FactorsNerve Tissue ProteinsNuclear ProteinsPromoter Regions, GeneticProtein BindingReceptors, N-Methyl-D-AspartateRNA, MessengerSp1 Transcription FactorTranscriptional ActivationConceptsMyocyte enhancer factor 2CSp1 sitesSp1 proteinMEF2 siteFactor 2CNMDA receptor subunit 1Results of yeastNR1 promoterMuscle transcription factorsCo-immunoprecipitation experimentsDifferentiated P19 cellsGrowth factorGrowth factor regulationTwo-hybridActivation domainSp1 cDNAEssential subunitTranscription factorsEpidermal growth factorP19 cellsFactor regulationPromoter activityFibroblast growth factorBasic fibroblast growth factorNeuronal development
1989
Growth Factors for Neuronal Survival and Process Regeneration: Implications in the Mammalian Central Nervous System
Lipton S. Growth Factors for Neuronal Survival and Process Regeneration: Implications in the Mammalian Central Nervous System. JAMA Neurology 1989, 46: 1241-1248. PMID: 2573331, DOI: 10.1001/archneur.1989.00520470113038.Peer-Reviewed Original ResearchConceptsNeuronal survivalClinical neurologistsMammalian central nervous systemCentral nervous systemPossible therapeutic approachesPotential clinical implicationsImmunodeficiency syndromeAxonal regenerationNeuronal transplantationNeurologic disordersTherapeutic approachesModulatory agentsNervous systemAlzheimer's diseaseClinical implicationsMammalian brainNerve growthNeuronal processesGrowth factorNeurologistsNumber of substancesDiseaseNeuronsProcess regenerationSurvivalAcidic Fibroblast Growth Factor Enhances Peripheral Nerve Regeneration in Vivo
Cordeiro P, Seckel B, Lipton S, D'Amore P, Wagner J, Madison R. Acidic Fibroblast Growth Factor Enhances Peripheral Nerve Regeneration in Vivo. Plastic & Reconstructive Surgery 1989, 83: 1013-1019. PMID: 2727148, DOI: 10.1097/00006534-198906000-00014.Peer-Reviewed Original ResearchConceptsPeripheral nerve regenerationAcidic fibroblast growth factorNerve regenerationGrowth factorNerve guidesEffect of aFGFNerve growth factorNerve guide tubesFibroblast growth factorMotor neuronsPrimary sensoryAxonal branchingMyelinated axonsExperimental modelAxonsVivoFactorsGreater numberNeurons
1988
Acidic fibroblast growth factor enhances regeneration of processes by postnatal mammalian retinal ganglion cells in culture.
Lipton S, Wagner J, Madison R, D'Amore P. Acidic fibroblast growth factor enhances regeneration of processes by postnatal mammalian retinal ganglion cells in culture. Proceedings Of The National Academy Of Sciences Of The United States Of America 1988, 85: 2388-2392. PMID: 3353388, PMCID: PMC279998, DOI: 10.1073/pnas.85.7.2388.Peer-Reviewed Original ResearchConceptsRat retinal ganglion cellsBasic fibroblast growth factorAcidic fibroblast growth factorRetinal ganglion cellsFibroblast growth factorGlial cellsGrowth factorProcess outgrowthGanglion cellsPostnatal rat retinal ganglion cellsMammalian retinal ganglion cellsOutgrowth of processesGlial fibrillary acidic proteinEffect of aFGFMammalian central nervous systemMammalian central neuronsRegeneration of processesFibrillary acidic proteinCentral nervous systemPeptide growth factorsRGC survivalHumoral effectsHeparin-like moleculesCentral neuronsAddition of heparin