1992
Blockade of NMDA receptor-mediated mobilization of intracellular Ca2+ prevents neurotoxicity
Lei S, Zhang D, Abele A, Lipton S. Blockade of NMDA receptor-mediated mobilization of intracellular Ca2+ prevents neurotoxicity. Brain Research 1992, 598: 196-202. PMID: 1486480, DOI: 10.1016/0006-8993(92)90183-a.Peer-Reviewed Original ResearchConceptsIntracellular Ca2Extracellular Ca2Excessive NMDA receptor stimulationRetinal ganglion cell neuronsNMDA receptor-mediated neurotoxicityGanglion cell neuronsNMDA receptor activationReceptor-mediated mobilizationNMDA receptor stimulationNormal extracellular Ca2Neuronal damagePharmacological interventionsPrevents neurotoxicityReceptor stimulationPresence of EGTAIntracellular storesNMDACell neuronsReceptor activationCultured ratDelayed neurotoxicityDantroleneNeurotoxicityElevated Ca2Neurons
1988
Central mammalian neurons normally resistant to glutamate toxicity are made sensitive by elevated extracellular Ca2+: toxicity is blocked by the N-methyl-D-aspartate antagonist MK-801.
Hahn J, Aizenman E, Lipton S. Central mammalian neurons normally resistant to glutamate toxicity are made sensitive by elevated extracellular Ca2+: toxicity is blocked by the N-methyl-D-aspartate antagonist MK-801. Proceedings Of The National Academy Of Sciences Of The United States Of America 1988, 85: 6556-6560. PMID: 2901101, PMCID: PMC282012, DOI: 10.1073/pnas.85.17.6556.Peer-Reviewed Original ResearchConceptsAntagonist MK-801MK-801N-methyl-D-aspartate (NMDA) receptor-coupled ion channelsExtracellular Ca2N-methyl-D-aspartate antagonist MK-801Rat retinal ganglion cellsReceptor-coupled ion channelsGlutamate-induced cell deathCentral mammalian neuronsRetinal ganglion cellsElevated extracellular Ca2Severe neurological insultPatch-clamp experimentsDementia complexNeuronal deathCentral neuronsGanglion cellsNeurological insultNeurotoxic effectsAlzheimer's diseaseNeurological disordersDegenerative disordersNerve cellsMammalian neuronsHuntington's disease
1987
Voltage‐dependent conductances of solitary ganglion cells dissociated from the rat retina.
Lipton S, Tauck D. Voltage‐dependent conductances of solitary ganglion cells dissociated from the rat retina. The Journal Of Physiology 1987, 385: 361-391. PMID: 2443669, PMCID: PMC1192350, DOI: 10.1113/jphysiol.1987.sp016497.Peer-Reviewed Original ResearchConceptsWhole-cell recordingsRetinal ganglion cellsGanglion cellsPatch pipetteMicroM TTXRat retinaAction potentialsMM TEASlow action potentialsPatch-clamp recordingsSingle-channel recordingsCentral mammalian neuronesConventional intracellular electrodesCurrent-clamp conditionsWhole-cell currentsVoltage-clamp experimentsIntracellular recordingsVoltage-clamp analysisPharmacological agentsExtracellular Ca2Inactivation time constantsMicroM Cd2Conventional intracellularElectrophysiological propertiesFast spikes
1977
Electrical and adaptive properties of rod photoreceptors in Bufo marinus. I. Effects of altered extracellular Ca2+ levels.
Lipton S, Ostroy S, Dowling J. Electrical and adaptive properties of rod photoreceptors in Bufo marinus. I. Effects of altered extracellular Ca2+ levels. The Journal Of General Physiology 1977, 70: 747-770. PMID: 412914, PMCID: PMC2228514, DOI: 10.1085/jgp.70.6.747.Peer-Reviewed Original ResearchConceptsReceptor sensitivityLight-evoked responsesResponse amplitudeLow calcium RingerMembrane potential levelMembrane potentialExtracellular Ca2Intracellular storesAdapted rodRod sensitivityReceptor potentialElectrical activityRod photoreceptorsRinger's solutionV-log IRingerDark adaptationProlonged exposureSensitivity recoveryRetinaResponse saturationSubstantial depolarizationBufo marinus