2024
“Dark” Pathways of Protein Transnitrosylation Injure Synapses in Alzheimer’s Disease: Mechanism and Potential Treatment
LIPTON S. “Dark” Pathways of Protein Transnitrosylation Injure Synapses in Alzheimer’s Disease: Mechanism and Potential Treatment. 2024, pl. DOI: 10.14869/toxpt.51.1.0_pl.Peer-Reviewed Original ResearchAlzheimer's diseaseDisruption of protein functionUbiquitin-protein hydrolaseS-nitrosylationS-nitrosylation reactionLoss of synapsesCorrelated to cognitive declineGuanosine triphosphataseMitochondrial fragmentationAD brainProtein functionAmyloid-betaAggregated proteinsProtein hydrolaseSynapse lossSynaptic lossBioenergetic compromiseSynaptic damageTransnitrosylation reactionsProteinUCH-L1Environmental factorsEnzymeAlzheimerCascade
1997
Suppression of neuronal apoptosis by S-nitrosylation of caspases
Tenneti L, D'Emilia D, Lipton S. Suppression of neuronal apoptosis by S-nitrosylation of caspases. Neuroscience Letters 1997, 236: 139-142. PMID: 9406756, DOI: 10.1016/s0304-3940(97)00780-5.Peer-Reviewed Original ResearchConceptsS-nitrosylationInterleukin-1beta-converting enzyme-like proteasesCritical cysteine residuesEnzyme-like proteasesApoptotic cell deathHuman embryonic kidneyTranscription factorsEnzyme familyCysteine residuesG proteinsEmbryonic kidneyCell deathCaspasesIon channelsPrimary cerebrocortical neuronsPhysiological activityEnzyme activityActive siteApoptosisNeuronal apoptosisCerebrocortical neuronsFamilyProteinProteaseEnzyme