2019
Mechanisms of hyperexcitability in Alzheimer’s disease hiPSC-derived neurons and cerebral organoids vs isogenic controls
Ghatak S, Dolatabadi N, Trudler D, Zhang X, Wu Y, Mohata M, Ambasudhan R, Talantova M, Lipton S. Mechanisms of hyperexcitability in Alzheimer’s disease hiPSC-derived neurons and cerebral organoids vs isogenic controls. ELife 2019, 8: e50333. PMID: 31782729, PMCID: PMC6905854, DOI: 10.7554/elife.50333.Peer-Reviewed Original ResearchConceptsDisease brainNeuronal culturesHuman Alzheimer's disease brainCerebral organoidsAD-related mutationsHiPSC-derived neuronsTransgenic AD miceInhibitory synaptic activityMechanisms of hyperexcitabilityAlzheimer's disease brainAberrant electrical activitySodium current densityAD micePathophysiological correlatesSynaptic dysfunctionAD pathophysiologyExcessive excitabilitySynaptic activityObserved hyperexcitabilityCognitive declineBursting activityHyperexcitabilityPresenilin 1Electrical activityNeurite length
1990
VIP-mediated increase in cAMP prevents tetrodotoxin-induced retinal ganglion cell death in vitro
Kaiser P, Lipton S. VIP-mediated increase in cAMP prevents tetrodotoxin-induced retinal ganglion cell death in vitro. Neuron 1990, 5: 373-381. PMID: 2169272, DOI: 10.1016/0896-6273(90)90173-d.Peer-Reviewed Original ResearchConceptsVasoactive intestinal peptideNatural cell deathRGC survivalRetinal ganglion cell deathRetinal ganglion cell neuronsCell deathGanglion cell deathGanglion cell neuronsElectrical blockadePHI-27VIP10-28Intestinal peptideAfferent influencesNeurotrophic effectsNeonatal ratsTetrodotoxin blockadeVIP stimulationRetinal culturesCell neuronsIntact retinaAdenylate cyclaseNormal cell deathElectrical activityDeathRGCs
1986
Blockade of electrical activity promotes the death of mammalian retinal ganglion cells in culture.
Lipton S. Blockade of electrical activity promotes the death of mammalian retinal ganglion cells in culture. Proceedings Of The National Academy Of Sciences Of The United States Of America 1986, 83: 9774-9778. PMID: 3025849, PMCID: PMC387224, DOI: 10.1073/pnas.83.24.9774.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsGanglion cellsNatural cell deathElectrical activityDeath of RGCsMammalian retinal ganglion cellsCell deathLevel of activityPostnatal day 2Spontaneous electrical activityElectrical blockadeIntraocular injectionMicroM tetrodotoxinPostnatal weekNeuronal activitySpontaneous activityTrophic factorsPostnatal ratsMammalian retinaDevelopment neuronsDay 2TetrodotoxinBlockadeIndividual neuronsAltered activity
1977
Electrical and adaptive properties of rod photoreceptors in Bufo marinus. II. Effects of cyclic nucleotides and prostaglandins.
Lipton S, Rasmussen H, Dowling J. Electrical and adaptive properties of rod photoreceptors in Bufo marinus. II. Effects of cyclic nucleotides and prostaglandins. The Journal Of General Physiology 1977, 70: 771-791. PMID: 201724, PMCID: PMC2228513, DOI: 10.1085/jgp.70.6.771.Peer-Reviewed Original ResearchConceptsCombination of drugsIsolated toad retinaCyclic nucleotide levelsCombination of IBMXResponse amplitudeDrug levelsReceptor sensitivityLong-term exposureReceptor saturationIntracellular cGMPMM IBMXRetinaControl RingerSimilar alterationsElectrical activityCGMPRod photoreceptorsV-log IATPase pumpRod activitySuperfusionDark adaptationOuter segmentsSensitivity recoveryCyclic nucleotidesElectrical and adaptive properties of rod photoreceptors in Bufo marinus. I. Effects of altered extracellular Ca2+ levels.
Lipton S, Ostroy S, Dowling J. Electrical and adaptive properties of rod photoreceptors in Bufo marinus. I. Effects of altered extracellular Ca2+ levels. The Journal Of General Physiology 1977, 70: 747-770. PMID: 412914, PMCID: PMC2228514, DOI: 10.1085/jgp.70.6.747.Peer-Reviewed Original ResearchConceptsReceptor sensitivityLight-evoked responsesResponse amplitudeLow calcium RingerMembrane potential levelMembrane potentialExtracellular Ca2Intracellular storesAdapted rodRod sensitivityReceptor potentialElectrical activityRod photoreceptorsRinger's solutionV-log IRingerDark adaptationProlonged exposureSensitivity recoveryRetinaResponse saturationSubstantial depolarizationBufo marinus