Blockade of NMDA receptor-mediated mobilization of intracellular Ca2+ prevents neurotoxicity
Lei S, Zhang D, Abele A, Lipton S. Blockade of NMDA receptor-mediated mobilization of intracellular Ca2+ prevents neurotoxicity. Brain Research 1992, 598: 196-202. PMID: 1486480, DOI: 10.1016/0006-8993(92)90183-a.Peer-Reviewed Original ResearchConceptsIntracellular Ca2Extracellular Ca2Excessive NMDA receptor stimulationRetinal ganglion cell neuronsNMDA receptor-mediated neurotoxicityGanglion cell neuronsNMDA receptor activationReceptor-mediated mobilizationNMDA receptor stimulationNormal extracellular Ca2Neuronal damagePharmacological interventionsPrevents neurotoxicityReceptor stimulationPresence of EGTAIntracellular storesNMDACell neuronsReceptor activationCultured ratDelayed neurotoxicityDantroleneNeurotoxicityElevated Ca2Neurons