1997
Mechanism of memantine block of NMDA‐activated channels in rat retinal ganglion cells: uncompetitive antagonism.
Chen H, Lipton S. Mechanism of memantine block of NMDA‐activated channels in rat retinal ganglion cells: uncompetitive antagonism. The Journal Of Physiology 1997, 499: 27-46. PMID: 9061638, PMCID: PMC1159335, DOI: 10.1113/jphysiol.1997.sp021909.Peer-Reviewed Original ResearchConceptsRat retinal ganglion cellsRetinal ganglion cellsMicroM memantineGanglion cellsUncompetitive antagonismAction of memantineDegree of blockadeConcentrations of NMDARapid superfusion systemWhole-cell recordingsConcentration of agonistDose-response relationshipLow agonist concentrationsNon-competitive actionDose-response curveOpen channel blockerOpen-channel blockadeMemantine actionEndogenous glutamateMicroM NMDAMemantine concentrationsSuperfusion systemMemantine blockMemantineNMDA
1992
l-Homocysteic acid selectively activates N-methyl-d-aspartate receptors of rat retinal ganglion cells
Zhang D, Lipton S. l-Homocysteic acid selectively activates N-methyl-d-aspartate receptors of rat retinal ganglion cells. Neuroscience Letters 1992, 139: 173-177. PMID: 1351663, DOI: 10.1016/0304-3940(92)90545-i.Peer-Reviewed Original ResearchConceptsRat retinal ganglion cellsRetinal ganglion cellsGanglion cellsRat RGCsN-methyl-D-aspartate receptorsNMDA receptor-channel complexConcentrations of NMDAL-homocysteic acidWhole-cell recordingsReceptor-channel complexRetinal transmittersMaximal responseHomocysteic acidNMDAPatch electrodePossible roleMillimolar concentrationsHCACellsReceptorsResponse
1988
The interaction of agonists and noncompetitive antagonists at the excitatory amino acid receptors in rat retinal ganglion cells in vitro
Karschin A, Aizenman E, Lipton. The interaction of agonists and noncompetitive antagonists at the excitatory amino acid receptors in rat retinal ganglion cells in vitro. Journal Of Neuroscience 1988, 8: 2895-2906. PMID: 2842467, PMCID: PMC6569411, DOI: 10.1523/jneurosci.08-08-02895.1988.Peer-Reviewed Original ResearchConceptsExcitatory amino acidsGanglion cellsMK-801Excitatory amino acid receptorsRat retinal ganglion cellsWhole-cell patch-clamp techniqueCultured ganglion cellsKainate-activated currentsKainate-induced currentsAmino acid receptorsConcentrations of NMDAApplication of kainateKainate-induced responsesPresence of NMDAReceptor-ion channel complexRetinal ganglion cellsNoncompetitive NMDA antagonistPatch-clamp techniqueDegree of blockAnticonvulsant MK-801Ganglion cell membraneDissociative anesthetic phencyclidineMicroM kainateKainate currentsLarge inward currents