1998
A phase I/II trial of nimodipine for HIV-related neurologic complications
Navia B, Dafni U, Simpson D, Tucker T, Singer E, McArthur J, Yiannoutsos C, Zaborski L, Lipton S. A phase I/II trial of nimodipine for HIV-related neurologic complications. Neurology 1998, 51: 221-228. PMID: 9674806, DOI: 10.1212/wnl.51.1.221.Peer-Reviewed Original ResearchConceptsAIDS dementia complexVoltage-dependent calcium channel antagonistsPhase I/II trialSevere AIDS-dementia complexHigh-dose armPhase II studyFurther clinical trialsCalcium channel antagonistsNPZ-8Adjuvant treatmentAntiretroviral therapyII trialNeurologic complicationsNeuropsychological z scoresNeuronal injuryHIV infectionPeripheral neuropathyTreat analysisCSF levelsDementia complexImmune activationClinical trialsNeurologic disordersChannel antagonistsPossible efficacy
1997
Neuropathogenesis of acquired immunodeficiency syndrome dementia
Lipton S. Neuropathogenesis of acquired immunodeficiency syndrome dementia. Current Opinion In Neurology 1997, 10: 247-253. PMID: 9229134, DOI: 10.1097/00019052-199706000-00014.Peer-Reviewed Original ResearchConceptsImmunodeficiency syndrome (AIDS) dementiaImmunodeficiency syndrome (AIDS) patientsPotential new treatmentCentral nervous systemDevelopment of therapiesAntiretroviral therapyNeuronal injuryBrain macrophagesImmunodeficiency syndromeAntiretroviral drugsNeuronal deathHuman immunodeficiencySurrogate markerClinical trialsSyndrome patientsDirect infectionCerebrospinal fluidNervous systemPast year progressNew treatmentsViral productsTherapyDementiaOne-thirdFurther characterization